[關(guān)鍵詞]
[摘要]
苦參堿和氧化苦參堿能濃度相關(guān)地抑制人視網(wǎng)膜母細胞瘤和翼狀胬肉成纖維細胞的增殖并誘導(dǎo)細胞凋亡,作用機制可能與激活內(nèi)質(zhì)網(wǎng)應(yīng)激的PERK/ATF4/CHOP信號通路和抑制PI3K/Akt信號通路有關(guān)??鄥A和氧化苦參堿也能濃度相關(guān)地抑制角膜成纖維細胞增殖并誘導(dǎo)細胞凋亡以及防治糖尿病視網(wǎng)膜病變和增殖性玻璃體視網(wǎng)膜病變??鄥A能抑制角膜移植后機體的排斥反應(yīng)以及防治感染性和非感染性眼炎、準分子激光屈光性角膜切削術(shù)術(shù)后的霧狀渾濁、后發(fā)性白內(nèi)障和眼壓升高。綜述苦參堿和氧化苦參堿防治眼病藥理作用的研究進展,以期為開發(fā)眼科新藥提供依據(jù)。
[Key word]
[Abstract]
Matrine and oxymatrine inhibit proliferation in association with dosage on retinoblastoma cells and pterygium fibroblasts, and induce apoptosis. Their mechanism may be related to excite endoplasmic reticulum stress PERK/ATF4/CHOP signaling pathway, and inhibit PI3K/Akt signaling pathway. Matrine and oxymatrine inhibit proliferation in association with dosage on corneal fibroblasts and induce apoptosis, and prevent and treat for diabetic retinopathy and proliferative vitreoretinopathy. Matrine inhibits bodily reject reaction after corneal allograft, and prevent and treat for infective and non-infective ophthalmitis, haze after PRK, posterior capsular opacification and increasing of intraocular pressue. The effects of matrine and oxymatrine to prevent and treat for ophthalmopathy were reviewed, in order to provide basis for the development of new ophthalmic drugs.
[中圖分類號]
R285.5
[基金項目]