胃癌是一種嚴重威脅人類生命健康的惡性腫瘤。姜黃素（curcumin）提取自姜黃Curcuma longa根莖，在體內(nèi)外藥理實驗中表現(xiàn)出良好的抗胃癌作用，且具有較高的安全性。姜黃素抗胃癌作用機制主要包括抑制胃癌細胞增殖、阻滯細胞周期、誘導細胞凋亡及自噬、調(diào)控相關信號通路及基因表達、抑制細胞侵襲及遷移、誘導活性氧產(chǎn)生、抑制腫瘤血管及淋巴管生成、化療增敏及逆轉化療耐藥、減少胃酸分泌等。就姜黃素抗胃癌藥理作用機制進行綜述，為其進一步研究及抗胃癌新藥研發(fā)提供參考。

Gastric cancer is a malignant tumor which threatens the human life and health seriously. Curcumin, a natural extract from the rhizome of turmeric (Curcuma longa), has shown potent anti-gastric cancer effects in many experiments both in vivo and in vitro, and has high security. The anti-gastric cancer mechanism of curcumin mainly includes inhibition of gastric cancer cell proliferation, arrest of cell cycle, induction of cell apoptosis and autophagy, regulation of related signaling pathways and gene expression, inhibi‐ tion of cell invasion and migration, induction of ROS generation, inhibiting tumor angiogenesis and lymphangiogenesis, chemo‐ therapy sensitization and reversal of chemotherapy resistance, and reducing gastric acid secretion. In this review, we summarize the mechanism of curcumin against gastric cancer to provide reference for the further study of curcumin against gastric cancer.

R285.5