0.05)。結(jié)論 安腦丸聯(lián)合丙戊酸鈉治療老年躁狂抑郁癥能顯著提高療效,減輕患者躁狂與抑郁程度,還可下調(diào)GSK3活性、炎癥因子表達(dá)水平,改善認(rèn)知能力,且不增加藥物不良反應(yīng)。;Objective To explore the clinical effect of Annao Pill combined with sodium valproate in the treatment of senile manic depression and its effect on glycogen synthase kinase 3 (GSK3) activity, inflammatory state and cognitive function. Methods A total of 92 elderly patients with manic depression treated in Jiaozuo Fourth People's Hospital from February 2018 to September 2020 were prospectively selected as the research objects. They were randomly divided into control group and experimental group, with 46 cases in each group. Patients in the control group were treated with Sodium Valproate Sustained-Release Tablets, with an initial dose of 500 mg once a day, within one week, it can be increased to 1 000—1 500 mg per day according to the patient's condition and tolerance. On the basis of the control group, patients in the experimental group were added with Annao Pill, with an initial dose of six g each time, twice a day, after two weeks, the dosage was adjusted to three g each time, one time a day. Both groups were treatedorally for eight weeks. The total effective rates of the two groups were compared. The manic symptoms and depressive symptoms of the two groups were evaluated by Bech-Rafaelsen Mania Rating Scale (BRMS) and Hamilton Depression Scale (HAMD) before and eight weeks after treatment. The levels of the GSK3 related protein in peripheral blood mononuclear cells (PBMC) and serum inflammatory factor tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and interleukin-10 (IL-10) were detected. Cognitive function were evaluated by Metacognitive questionnaire (MCQ-30), and the adverse reactions of the two groups were observed and recorded. Results After eight weeks of treatment, the total effective rate in the experimental group was 93.48%, which was significantly higher than 78.26% in the control group (P < 0.05). After eight weeks of treatment, the scores of BRMS and HAMD in the two groups decreased compared with those before treatment (P < 0.05), and the scores in the experimental group were lower than those in the control group (P < 0.05). The levels of pSer21-GSK3α, pSer9-GSK3β, total-GSK3α, total-GSK3β in PBMC and serum IL-10 of the two groups after eight weeks of treatment were higher than those before treatment (P < 0.05), and the levels in the experimental group were higher than those in the control group (P < 0.05). The level of serum TNF-α and IL-1 of the two groups after eight weeks of treatment were lower than that those before treatment (P < 0.05), and the levels in the experimental group were lower than those in the control group (P < 0.05). After eight weeks of treatment, the scores of MCQ-30 scale cognitive selfconfidence, self-awareness, positive belief, tendency to control thinking, out of control and sense of crisis in the two groups were higher than those before treatment (P < 0.05), and those in the experimental group were higher than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the experimental group and the control group (P>0.05). Conclusion The combination of Annao Pill and sodium valproate in the treatment of senile manic depression can significantly improve the curative effect, reduce the degree of mania and depression, reduce the activity of GSK3 and the expression level of inflammatory factors, improve cognitive ability, and do not increase adverse drug reactions."/>

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首頁 > 過刊瀏覽>2022年第45卷第2期 >2022,45(2):343-349. DOI:10.7501/j.issn.1674-6376.2022.02.021
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安腦丸聯(lián)合丙戊酸鈉對老年躁狂抑郁癥患者的治療效果及GSK3活性、炎癥狀態(tài)、認(rèn)知功能的影響

Therapeutic effects of Annao Pill and sodium valproate in treatment of elderly patients with manic depression and its influence on GSK3 activity, inflammatory state and cognitive function

發(fā)布日期:2022-02-16
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