樺褐孔菌Inonotus obliquus屬于多孔菌科褐臥孔菌屬，是珍貴的藥用真菌，分布于中國、芬蘭、波蘭、俄羅斯及日本等國家。樺褐孔菌具有抗衰老和抑制病毒的藥理作用，主要用于治療各種癌癥、糖尿病及心臟病，主要成分為多糖、三萜類化合物、木質(zhì)素及黑色素，其提取分離方法主要涉及水提法、超聲法、微波輔助提取法、酶誘導(dǎo)結(jié)合負(fù)壓空氣化提取法，分析方法主要為薄層色譜法、高效液相法和紫外-分光光度法。天然產(chǎn)物在新藥研發(fā)及新藥先導(dǎo)化合物發(fā)現(xiàn)中起重要作用，綜述了樺褐孔菌活性成分的提取及分析方法研究進(jìn)展，以期為其深入研究及新藥研發(fā)提供參考。

Inonotus obliquus is a valuable medicinal fungus belonging to the genus Obliquus of the family poraceae. It is distributed in China, Finland, Poland, Russia and Japan. It is mainly used worldwide to treat various cancers, diabetes and heart disease. In addition, it has anti-aging and anti-virus effects. The main ingredient of fo to the polysaccharides of fo, triterpene compounds, melanin and lignin, the extraction and separation methods mainly involves water, ultrasonic method, microwave assisted extraction, enzyme induction combined with negative pressure air extraction, analysis method for thin layer chromatography (TLC), high performance liquid (HPLC) and ultraviolet spectrophotometer method. Natural products play an important role in the discovery of new drugs and new drug lead compounds. In this paper, the extraction methods and analysis methods of active substances in Inonotus obliquus were reviewed, in order to provide reference for the further study of active substances in Inonotus obliquus e and the development of natural fungi as precursor compounds for new drug research and development.

R917

黑龍江省應(yīng)用技術(shù)研究與開發(fā)計劃資助項目（GA19C107）；黑龍江省應(yīng)用技術(shù)研究與開發(fā)計劃（GA19C009）