苦參堿可防治高糖、高脂引起的心血管并發(fā)癥，脂肪肝并發(fā)癥，糖尿病視網(wǎng)膜病變，糖尿病腎病以及肺、腹膜纖維化并發(fā)癥?？鄥A防治這些并發(fā)癥的藥理機制可能是：（1）苦參堿的降血糖、調(diào)血脂及抗氧化作用，從源頭上減少了氧化型低密度脂蛋白和晚期糖基化終末產(chǎn)物的生成；（2）苦參堿的抗氧化、抗炎和細(xì)胞保護作用可保護和修復(fù)β細(xì)胞，促進胰島素合成與分泌，也可保護累及的心血管系統(tǒng)、腎臟、肝臟、肺和視網(wǎng)膜等其他器官，減輕胰島素抵抗，提高胰島素敏感性。因此，苦參堿有開發(fā)成為治療代謝綜合征新藥的潛力。

Matrine protects and treats for cardiovascular complication, fatty liver complication, diabetic retinopathy, diabetic renopathy, and the complications of lung and peritoneum fibrosis induced by hyperglycystia and hyperliposis. These mechanisms to protect and treat for complications are: (1) the effects of matrine on hypoglycemia, hypolipemia and antioxidation decrease the products of AGEs and ox-LDL from source, (2) the effects on antioxidation, anti-inflammation and cellular protection of matrine protect and repair islet beta cells, improve the synthesis and secretion of insulin, protect suffering organs of cardiovascullar system, ren, liver, lung and retina, alleviate insulin resistance, and increase insulin sensitivity. So matrine has potentiality to become a drug of treating metabolic syndrome.

R287.5