圍絕經(jīng)期綜合征是女性絕經(jīng)前后的常見疾病，臨床研究發(fā)現(xiàn)六味地黃丸治療該病具有較好的療效。經(jīng)典名方六味地黃丸由熟地黃、山茱萸、山藥、澤瀉、牡丹皮、茯苓6味中藥組方，可有效改善患者的血管舒縮、情緒失常、睡眠障礙、脂代謝紊亂、骨質(zhì)流失等癥狀，其藥效機制可能在于調(diào)節(jié)患者的雌激素水平，進而改善患者全身癥狀。綜述六味地黃丸治療圍絕經(jīng)期綜合征的臨床研究進展，以期為后續(xù)臨床和實驗研究提供參考。

Menopausal syndrome is a common disease of women, that occur during the perimenopausal and early postmenopausal period. Liuwei Dihuang Pill has been found to have obvious therapeutic effects on the disease. This classic formula is composed of six traditional Chinese herbs, including Rehmanniae Radix Praeparata, Corni Fructus, Dioscoreae Rhizoma, Alismatis Rhizoma, Moutan Cortex, Poria, which improves body composition in patients with menopausal syndrome, including vasomotor symptoms, mood disturbances, interrupted sleeping patterns, lipid metabolism disorders, bone loss, genitourinary symptoms and others. Its mechanism may lie in regulating the estrogen of patients, thereby improving the systemic symptoms of patients, hoping to provide directions and references for future research.

R287.5

國家科技重大專項資助項目（2018ZX09737-019）；天津市自然科學(xué)基金重點項目（20JCZDJC00010）；釋藥技術(shù)與藥代動力學(xué)國家重點實驗室（天津藥物研究院）開發(fā)課題資助項目（010162001）