和厚樸酚及厚樸酚是疏水性聯(lián)苯酚類結(jié)構(gòu)的同分異構(gòu)體。和厚樸酚能防治結(jié)直腸癌CT26細(xì)胞或RKO細(xì)胞移植瘤在小鼠體內(nèi)生長，并延長荷瘤小鼠的生存時(shí)間。體外實(shí)驗(yàn)發(fā)現(xiàn)和厚樸酚及厚樸酚能濃度相關(guān)地抑制結(jié)直腸癌SW480細(xì)胞、SW620細(xì)胞、LoVo細(xì)胞、LS180細(xì)胞、CT26細(xì)胞、RKO細(xì)胞、Caco-2細(xì)胞、COLO-205細(xì)胞、HCT-8細(xì)胞、HCT15細(xì)胞、HCT116細(xì)胞增殖，并誘導(dǎo)細(xì)胞凋亡。在HCT116細(xì)胞中，hMLH1錯(cuò)配修復(fù)缺失型細(xì)胞對(duì)和厚樸酚的敏感性高于完整型細(xì)胞。和厚樸酚是通過調(diào)控JNK/Nur77/AMPK、TGF-β1/p38MAPK/Hippo、BMP7/TGF-β1/p53和BMP7/PTEN/AKT 4條信號(hào)轉(zhuǎn)導(dǎo)通路誘導(dǎo)結(jié)直腸癌細(xì)胞凋亡，還通過抑制血管內(nèi)皮生長因子的表達(dá)，阻滯腫瘤內(nèi)新生血管形成，抑制結(jié)直腸癌生長。和厚樸酚及厚樸酚還能抑制胃癌MGC-803細(xì)胞和SGC-7901細(xì)胞的增殖。

Honokiol and magnolol are hydrophobic isomer of biphenol-type structure. Honokiol has the effects in the prophylaxis and treatment for growth of transplantation tumor of colorectal cancer CT26 cells or RKO cells in mice and prolong survival time in mice with bearing tumor. Honokiol and magnolol inhibit proliferation and induce apoptosis in association with dosage on colorectal cancer SW480 cells, SW620 cells, LoVo cells, LS180 cells, TC26 cells, RKO cells, Caco-2 cells, COLO-205 cells, HCT-9 cells, HCT15 cells, and HCT116 cells in vitro. In HCT116 cells, sensibility of hMLH1 mismatch repair defective HCT116 cells to honokiol is higher than hMLH1 mismatch repair proficient HCT116 cells. Honokiol induces colorectal cancer cells apoptosis by regulating four signaling pathways of JNK/Nur77/AMPK, TGF-β1/p38MAPK/Hippo, BMP7/TGF-β1/p53, and BMP7/PTEN/AKT. Honokiol inhibits too growth of colorectal cancer cells by down-regulating the expression of VEGF and decreasing tumor angiogenesis. Honokiol and magnolol inhibit proliferation of gastric carcinoma MGC-803 cells and SGC-7901 cells.

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