地龍是傳統(tǒng)中藥，具有清熱定驚、通絡(luò)、平喘等功效，臨床常用于治療高熱神昏、肺熱咳喘、半身不遂等。地龍所含化學(xué)成分眾多，其中氨基酸類、多肽類、核苷類和有機(jī)酸等類化合物為其主要活性成分?，F(xiàn)代藥理研究表明地龍具有抗炎、抗血栓、心臟保護(hù)、抗腫瘤和改善呼吸系統(tǒng)功能等作用。總結(jié)了近年來(lái)國(guó)內(nèi)外有關(guān)地龍化學(xué)成分、藥理活性相關(guān)文獻(xiàn)，對(duì)其研究進(jìn)展進(jìn)行綜述，為地龍的藥物開(kāi)發(fā)及臨床應(yīng)用提供依據(jù)。

Pheretima is a traditional Chinese medicine. It has the effects of clearing heat, calming convulsion, unblocking collaterals and relieving asthma. It is often used clinically for the treatment of high fever, dizziness, lung heat, cough asthma and hemiplegia. Pheretima contains many chemical components, among which amino acids, polypeptides, nucleosides and organic acids are the main ingredients. Modern pharmacological studies showed that Pheretima has anti-inflammatory, antithrombosis, cardioprotection, antitumor and respiratory system improvement effects. This article summarizes the research progress on chemical components and pharmacology of Pheretima in recent years for providing a basis for pheretima drug development and clinical application.

R285.5

國(guó)家重點(diǎn)研發(fā)計(jì)劃資助項(xiàng)目(2019YFC1711000)