青黛（Indigo Naturalis)是傳統(tǒng)中藥，臨床上已經(jīng)用于治療銀屑病、急性早幼粒細胞白血病和潰瘍性結(jié)腸炎。潰瘍性結(jié)腸炎是一種慢性非特異性的炎癥性腸病，近年來發(fā)病率逐漸上升。青黛及其效成分靛藍和靛玉紅治療潰瘍性結(jié)腸炎時取得顯著療效，其藥理作用機制涉及抗炎、促黏膜愈合、維護腸道免疫穩(wěn)態(tài)和調(diào)節(jié)腸道菌群等多個方面。對近年來青黛及其有效成分靛藍和靛玉紅抗?jié)冃越Y(jié)腸炎的藥理作用及其機制進行總結(jié)，以期為臨床合理用藥及抗?jié)冃越Y(jié)腸炎新藥研發(fā)提供依據(jù)。

Indigo Naturalis, a traditional Chinese medicine, has been extensively used in the treatment of psoriasis, acute promyelocytic leukemia and ulcerative colitis (UC). UC is a chronic, nonspecific inflammatory disease of intestine with gradually increasing incidence in recent years. Indigo Naturalis and its active ingredients, indigo and indirubin, have been applied to treat UC with significant curative effects. The mechanisms include anti-inflammation, mucosal healing, and intestinal immune homeostasis maintaining. This article summarizes the pharmacological actions and potential mechanisms of Indigo Naturalis, indigo and indirubin in the treatment of UC in recent years, which provides some reference for the safety of clinical medication and drug discovery.

R285.5

國家自然科學(xué)基金面上資助項目(81873084,81573690);雙一流高校資助項目(CPU2018GY06)