上海美優(yōu)制藥有限公司，上海201204

Honokiol and magnolol are hydrophobic isomer of propenyl biphenol-type structure. Honokiol has the effects in the prophylaxis and treatment for growth or lung metastasis of transplantation tumor of liver cancer HepG2 cells or H22 cells, gallblandder cancer SGC-996 cells or GBC-SD Cells, pancreatic cancer PANC-1 cells in nude mice. Magnolol has the prophylaxis and treatment for growth of transplantation tumor of PANC-1 cells in nude mice. Honokiol and magnolol inhibit proliferation and induce apoptosis in association with dosage on liver cancer HepG2 cells, Hep3B cells, SMMC-7721 cells, HCCLM3 cells, H22 cells, 7703 cells, and gallbladder cancer SGC-996 cells, GBC-SD cells, N02 cells, OCUG-1 cells, and pancreatic cancer PANC-1 cells, SW1990 cells, Miapaca cells, CFPAC-1 cells, ASPC-1 cells, MIAPa Ca cells in vitro. Honokiol and magnolol inhibit proliferation, migration and invasion by activating p38MAPK signal, and inhibiting NF-κB sjgnal, and regulating signaling pathway of JNK/DR and JNK/Nur77/AMPK, and down-regulating signaling pathways of Wnt/β-catenin, TGF-β1/Smad and PI3K/AKT, and up-regulating the expression of cathepsin D, reversing epithelial mesenchymal transition (EMT).

R285.5