靶向代謝組學(xué)是代謝組學(xué)的重要組成部分，對(duì)目標(biāo)明確的代謝產(chǎn)物在樣本中的含量進(jìn)行檢測(cè)，具有特異性強(qiáng)、檢測(cè)靈敏度高和定量準(zhǔn)確等特點(diǎn)。應(yīng)用靶向代謝組學(xué)研究疾病發(fā)生發(fā)展過(guò)程中的差異代謝物并闡明其代謝異常的機(jī)制，對(duì)疾病診斷及治療具有重要意義。將靶向代謝組學(xué)在糖尿病周?chē)窠?jīng)病變、糖尿病視網(wǎng)膜病變、糖尿病腎病、糖尿病性認(rèn)知功能障礙、糖尿病性心肌病及糖尿病性黃斑水腫中的應(yīng)用進(jìn)行歸納，整合不同疾病發(fā)生發(fā)展涉及的氨基酸代謝、脂代謝、三羧酸循環(huán)及糖酵解等多種代謝途徑及相關(guān)的差異代謝物，整理了不同并發(fā)癥的部分生物標(biāo)志物，以期為后續(xù)深入研究、尋找疾病治療新途徑提供思路和方法。

Targeted metabolomics is an important part of metabolomics, which is used to detect the target metabolites in samples. It has the characteristics of strong specificity, high detection sensitivity and accurate quantification. The application of targeted metabolomics to study the differential metabolites in the disease occurrence and development process and to clarify the mechanism of their abnormal metabolism is of great significance for disease diagnosis and treatment. This article summarizes the application of targeted metabolomics in diabetic peripheral neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cognitive dysfunction, diabetic cardiomyopathy and diabetic macular edema. Integrating amino acid metabolism, lipid metabolism, tricarboxylic acid cycle, glycolysis and other metabolic pathways and related differential metabolites involved in the occurrence and development of different diseases, and sorting out some biomarkers of different complications, to provide some ideas and methods for subsequent in-depth research and finding new ways of disease treatment.

R969.1

國(guó)家自然科學(xué)基金資助項(xiàng)目(81774014)