[關(guān)鍵詞]
[摘要]
目的 比較鹽酸丙卡特羅口服溶液口服聯(lián)合布地奈德霧化與硫酸特布他林霧化液霧化吸入聯(lián)合布地奈德霧化治療兒童咳嗽變異性哮喘患兒的有效性和經(jīng)濟(jì)性。方法 納入2020年1月—2020年12月上海中醫(yī)藥大學(xué)附屬龍華醫(yī)院收治的120例咳嗽變異性哮喘患兒,按隨機(jī)數(shù)字表法將其分為丙卡特羅組與特布他林組,每組各60例。丙卡特羅組予以布地奈德霧化聯(lián)合鹽酸丙卡特羅口服溶液口服治療,特布他林組予以布地奈德聯(lián)合硫酸特布他林霧化治療。評(píng)估兩組療效和安全性。比較兩組治療前后1秒用力呼氣容積(FEV1)、用力肺活量(FVC)、呼氣峰值流速(PEF)、嗜酸性粒細(xì)胞(EOS)、免疫球蛋白E(IgE)水平。比較兩組成本-效果。結(jié)果 特布他林組總有效率(96.67%)顯著高于丙卡特羅組(86.67%,P<0.05)。兩組患兒治療后FEV1、FVC、PEF顯著高于治療前(P<0.05),特布他林組患兒FEV1、FVC、PEF顯著高于丙卡特羅組(P<0.05)。兩組患兒治療后EOS和IgE水平顯著低于治療前(P<0.05),特布他林組患兒EOS和IgE水平顯著低于丙卡特羅組(P<0.05)。特布他林組患兒不良反應(yīng)發(fā)生率與丙卡特羅組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。丙卡特羅組治療經(jīng)濟(jì)學(xué)顯著優(yōu)于特布他林組(P<0.05)。結(jié)論 與丙卡特羅口服液相比,硫酸特布他林霧化吸入治療兒童咳嗽變異性哮喘可能具有較好效果及安全性,但丙卡特羅口服液具有更高經(jīng)濟(jì)價(jià)值。
[Key word]
[Abstract]
Objective To compare the efficacy and economy of procaterol hydrochloride oral solution combined with budesonide nebulization and terbutaline sulfate atomization inhalation combined with budesonide nebulization in treatment of children with cough variant asthma. Methods A total of 120 children with cough variant asthma treated in Longhua Hospital Shanghai University of Traditional Chinese Medicine from January 2020 to December 2020 were randomly divided into procaterol group and terbutaline group, with 60 cases in each group. Children in procaterol group were treated with budesonide nebulization combined with procaterol hydrochloride oral solution, and children in terbutaline group were treated with budesonide nebulization combined with terbutaline sulfate nebulization. The efficacy and safety of two groups were evaluated. The levels of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEF), eosinophils (EOS) and immunoglobulin E (IgE) were compared between two groups before and after treatment. The cost-effectiveness of two groups were compared. Results The total effective rate of terbutaline group (96.67%) was significantly higher than that of procaterol group (86.67%, P < 0.05). After treatment, FEV1, FVC and PEF in two groups were significantly higher than those before treatment (P < 0.05), and FEV1, FVC and PEF in terbutaline group were significantly higher than those in procaterol group (P < 0.05). The levels of EOS and IgE in two groups after treatment were significantly higher than those before treatment (P < 0.05), and the levels of EOS and IgE in terbutaline group were significantly lower than those in procaterol group (P < 0.05). There was no significant difference in incidence of adverse reactions between terbutaline group and procaterol group (P > 0.05). The therapeutic economics of procaterol group was significantly better than that of terbutaline group (P < 0.05). Conclusion Compared with procaterol oral liquid, terbutaline sulfate nebulized inhalation may have better effect and safety in treatment of variant asthma in children, but procaterol oral liquid has higher economic value.
[中圖分類號(hào)]
R974
[基金項(xiàng)目]
上海市臨床重點(diǎn)專科建設(shè)項(xiàng)目(shslczdzk04102)