和厚樸酚具有廣泛的生物活性，如抗菌、抗病毒、抗腫瘤、抗炎、抗氧化和抗衰老作用，對消化、神經(jīng)、心血管和呼吸系統(tǒng)等均有明顯的藥理活性。和厚樸酚是一種疏水性聯(lián)苯酚類結(jié)構(gòu)化合物，難溶于水，易溶于脂，在胃腸道吸收較差，但分布廣泛，50%以上口服劑量的和厚樸酚經(jīng)胃腸道排出體外，40%以上的和厚樸酚經(jīng)代謝后排出體外。通過綜述和厚樸酚藥動學(xué)參數(shù)，體內(nèi)過程，總結(jié)和厚樸酚的藥動學(xué)研究進(jìn)展，為合理用藥提供參考。

Honokiol has widespread bioactivities, including anti-bacteria, anti-virus, anticancer, anti-inflammation, antioxidation and anti-aging, and has significant pharmacologic activities to alimentary system, nervous system, cardiovascular system and respiratory system. Honokiol is a hydrophobic compound of biphenol-type structure, and hardly dissolves in water, and freely dissolves in lipid. Honokiol is poorly absorbed in gastrointestinal tract, and widely distributed. 50% above oral dosage of honokiol is excluded from gastrointestinal tract, and 40% above dosage is excluded by metabolism. The pharmacokinectic parameters and process in body of honokiol are reviewed, and its research advances on pharmacokinetics is summarized, which provides a reference for rational utilization of honokiol.

R969.1