結直腸癌是我國第3大常見癌癥，發(fā)病率、死亡率逐年上升。由于耐藥導致結直腸癌化療失敗的報道不斷增多，迫切需要尋找新的藥物作為化療藥物的增敏劑。以中藥活性成分為研究重點，發(fā)現姜黃素、白藜蘆醇、人參皂苷等中藥活性成分可以通過調控相關蛋白表達、自噬、上皮間充質轉化、癌癥干細胞、有氧糖酵解等途徑逆轉結直腸癌耐藥性。對逆轉結直腸癌耐藥性的中藥活性成分及其藥理作用機制加以總結，以期為結直腸癌治療提供更多選擇。

Colorectal cancer is the third most common cancer in China. Its morbidity and mortality are increasing year by year. Due to the increasing reports of chemotherapy failure of colorectal cancer caused by drug resistance, it is urgent to find new drugs to improve the efficacy of chemotherapy drugs. More and more scholars began to focus on the active components of traditional Chinese medicine. Curcumin, resveratrol, ginsenosides and other active ingredients of traditional Chinese medicine can reverse the drug resistance of colorectal cancer by regulating the expression of related proteins, autophagy, epithelial-mesenchymal transformation, cancer stem cells and aerobic glycolysis. The active components of traditional Chinese medicine that reverse drug resistance of colorectal cancer and their pharmacological mechanism were reviewed, in order to provide more theoretical reference for colorectal cancer chemotherapy.

R285.5;R286.5

陜西省自然科學基礎研究計劃面上項目（2021JM-474）；咸陽市中青年科技領軍人才項目（2020K04-01）