為了解納米原料作用于皮膚時的暴露情況和總體風(fēng)險，探討透皮吸收研究在納米原料安全評估中的應(yīng)用，對三聯(lián)苯基三嗪、氧化鋅、炭黑、二氧化鈦、亞甲基雙-苯并三唑基四甲基丁基酚5種已收錄于歐盟化妝品法規(guī)的納米原料的透皮吸收試驗研究以及相關(guān)安全評估工作進行總結(jié)。結(jié)果顯示皮膚對于這5種納米原料具有較好的屏障作用，未來在進行納米原料透皮吸收研究以及納米化妝品、經(jīng)皮給藥納米藥物的安全性評價時，應(yīng)充分考慮皮膚屏障作用的影響，結(jié)合納米原料的質(zhì)量規(guī)格關(guān)鍵參數(shù)進行逐案分析。

In order to understand the percutaneous exposure and overall risk of nanomaterials when applied on skin, and to discuss the application of percutaneous absorption data in safety evaluation of nanomaterials, in this article, the authors summarized related research studies and safety evaluation work of five nanomaterials, such as triphenyltriazine, zinc oxide, carbon black, titanium dioxide, methylene bis benzotriazolyl tetramethyl butylphenol, that had been included in the EU regulation. The results show that skin is an effective barrier for these nanomaterials. In the future, for percutaneous absorption study of nanomaterials, as well as for the safety evaluation of nano-cosmetics and skin-applied nano-drugs, the influence of skin barrier function should not be ignored, and a case-by-case analysis with consideration of key parameters of the nanomaterial is necessary.

R944;R986