旋覆花在中國有悠久的藥用歷史，具有降氣、消痰、行水、止嘔的功效，為中醫(yī)臨床治療風(fēng)寒咳嗽、痰飲蓄結(jié)、胸膈痞悶、喘咳痰多、嘔吐噫氣、心下痞硬的常用藥，是具有沉降藥性的代表藥味?，F(xiàn)代藥學(xué)研究表明旋覆花主要含有倍半萜類、黃酮類、其他萜類、甾體類、揮發(fā)油、多糖類等多種化合物，旋覆花及其有效成分具有抗炎、抗腫瘤、神經(jīng)保護(hù)、抗衰老、降糖調(diào)脂、抗過敏、抗動脈硬化、抗心肌損傷、抗氧化、抗黑色素生成、抗肝損傷等多方面的藥理活性。對《中國藥典》收載的2種旋覆花的化學(xué)成分及藥理作用研究進(jìn)展進(jìn)行總結(jié)和歸納，為進(jìn)一步闡明旋覆花沉降藥性的科學(xué)內(nèi)涵提供文獻(xiàn)依據(jù)。

Inulae Flos has a long history of medicinal use in China, with the effect of descending the adverse qi flow, resolving phlegm, promoting diuresis and stopping nausea. It is commonly used in the clinical treatment of cough due to wind-cold, stuffy and full sensation in the chest and diaphragm, dyspnea and cough with excessive sputum, vomiting, ructation, epigastric fullness and rigidity due to retention of phlegm and morbid fluids. It is a classical drug with descending medicinal properties. It mainly contains sesquiterpenoids, flavonoids, other terpenoids, steroids, volatile oils, polysaccharides and other compounds. Modern pharmacological research has shown that it has various pharmacological activities such as anti-inflammatory, anti-tumor, neuroprotective, anti-aging, reduce blood sugar, anti-lipidemic, anti-allergic, anti-atherosclerosis, anti-cardiac damage, antioxidant, anti-melanogenic, and anti-liver damage. The progress of research on the chemical composition and pharmacological effects of the pharmacopoeial base species of Inulae Flos in recent years were summarized, and provide a documentary basis for further elucidating the scientific connotation of the descending medicinal properties of Inulae Flos.

R284.2;R285.5

國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目(2019YFC1708803)