目的 觀察清咳平喘顆粒聯(lián)合頭孢克洛和鹽酸氨溴索治療兒童急性支氣管炎的臨床療效。方法 前瞻性將 2020 年 8月-2021 年 12 月上海市(復(fù)旦大學(xué)附屬)公共衛(wèi)生臨床中心收治的急性支氣管炎患兒 166 例納入研究,采用隨機(jī)數(shù)字表法,分為對照組和試驗(yàn)組。對照組給予頭孢克洛干混懸劑和鹽酸氨溴索口服溶液治療,試驗(yàn)組在對照組基礎(chǔ)上聯(lián)用清咳平喘顆粒,均治療 7 d。觀察比較兩組患兒臨床癥狀改善狀況及治療效果。觀察兩組患兒用藥期間咳嗽、咳痰、發(fā)熱、肺部啰音情況;觀察兩組患兒治療前后血清炎癥因子白細(xì)胞介素-1β(IL-1β)、白細(xì)胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)水平變化及咳嗽中醫(yī)證候積分,統(tǒng)計(jì)不良反應(yīng)發(fā)生情況。結(jié)果 最終共 160 例患兒完成研究,對照組和試驗(yàn)組各 80 例,試驗(yàn)組總有效率(87.50%)顯著高于對照組(80.00%)(P<0.05);治療后試驗(yàn)組咳嗽、咳痰、發(fā)熱、肺部啰音癥狀消失時(shí)間均顯著短于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組治療后咳嗽中醫(yī)證候積分以及炎癥因子均較本組治療前降低(P<0.05),且試驗(yàn)組降低更明顯(P<0.05)。兩組患兒不良反應(yīng)發(fā)生率分別為 5.00%、3.75%,無統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論 清咳平喘顆粒聯(lián)合頭孢克洛干混懸劑和鹽酸氨溴索口服溶液治療兒童急性支氣管炎有協(xié)同作用,可明顯改善患兒臨床癥狀,降低炎癥因子水平,縮短患兒病程,提高療效。

Objective To observe the clinical effect of Qingke Pingchuan Granules combined with cefaclor and ambroxol hydrochloride on acute bronchitis in children. Methods A total of 166 children with acute bronchitis were randomly divided into observation group (n=83) and control group (n=83). The the control group was treated with cefaclor dry suspension and ambroxol hydrochloride oral solution, while the observation group was treated with the qingke pingchuan granules on top of the control group for seven days. The improvement of clinical symptoms and treatment effects were compared between the two groups. Cough, expectoration, fever and lung rales were observed.Observe the changes of WBC, hs-CRP, PCT, serum inflammatory factors (IL-1β, IL-6, TNF-α, hs-CRP) and TCM syndrome score of cough before and after treatment, and count the adverse reactions. Results A total of 160 children completed the study, 80 cases in the control group and 80 cases in the observation group. The total effective rate of the observation group (87.50%) was significantly higher than that of the control group (80.00%) (P<0.05); After treatment, the indexes of cough, expectoration, fever and lung rale in the two groups were significantly improved compared with those before treatment (P<0.05). The clinical therapeutic effects of cough, expectoration, fever and lung rale in the observation group were significantly better than those in the control group, and the differences were statistically significant (P<0.05). The TCM syndrome score of cough and inflammatory factors in the two groups after treatment were lower than those before treatment (P<0.05), and the decrease was more obvious in the observation group (P<0.05). The incidence of adverse reactions in children in the control and observation groups was 5.00% and 3.75%, respectively, with no statistical significance (P > 0.05). Conclusion The synergistic effect of qingke pingchuan granules combined with cefaclor dry suspension and ambroxol hydrochloride oral solution in the treatment of acute bronchitis in childrensignificantly improves clinical symptoms, shortens the treatment process, improves, the treatment effect.

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