白藜蘆醇是一種天然單體化合物,屬于非黃酮類的多酚化合物,存在于多種植物中。現(xiàn)代藥理研究發(fā)現(xiàn),白藜蘆醇具有抗炎、抗氧化、抗腫瘤、調(diào)節(jié)代謝與機(jī)體免疫等藥理活性。白藜蘆醇對結(jié)腸癌、胰腺癌、卵巢癌、乳腺癌等多種腫瘤細(xì)胞均有抑制作用,其抗腫瘤作用逐漸成為研究熱點(diǎn)。白藜蘆醇可以通過抑制腫瘤細(xì)胞的增殖、誘導(dǎo)腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞侵襲和轉(zhuǎn)移、調(diào)節(jié)機(jī)體免疫功能、直接作用于相關(guān)靶點(diǎn)等發(fā)揮抗腫瘤活性。就白藜蘆醇在不同腫瘤細(xì)胞中發(fā)揮的抗腫瘤作用及其機(jī)制進(jìn)行綜述,以期為抗腫瘤新藥的研發(fā)提供參考依據(jù)。

Resveratrol is a natural compound that belongs to the non-flavonoid group of polyphenol compounds found in a variety of plant bodies. Modern research has found that resveratrol has pharmacological activities such as anti-inflammatory, antioxidant,antitumor,and regulation of metabolism and organism immunity. Resveratrol has inhibitory effects on colon cancer, pancreatic cancer, ovarian cancer, breast cancer and many other tumor cells, and its anti-tumor effects are gradually becoming a hot spot for research. Resveratrol can exert anti-tumor activity by inhibiting the proliferation of tumor cells, inducing apoptosis, inhibiting tumor cell invasion and metastasis, regulating the body's immune function, and acting directly on the relevant targets. By reviewing the domestic and international literature in recent years, the role and mechanism of resveratrol in different tumor cells were reviewed in order to provide a reference basis for the development of new anti-tumor drugs.

R285.5

國家重點(diǎn)研發(fā)計劃資助項(xiàng)目(2018YFC1707410-03)