和厚樸酚是二酚型疏水化合物，對糖尿病、血管緊張素II、膿毒癥、燒傷、冠脈結(jié)扎缺血、缺血再灌注等引起的心肌損傷都有保護作用，能阻滯心肌肥厚和纖維化的發(fā)生發(fā)展。和厚樸酚能拮抗脂多糖或氧化型低密度脂蛋白引起的血管內(nèi)皮細(xì)胞損傷，也能抑制血管平滑肌細(xì)胞增殖、遷移及血管重塑和血管新生，抑制氣囊血管形成術(shù)誘導(dǎo)新內(nèi)膜形成和血管狹窄，心血管保護作用的基本機制是抗氧化、抗炎、調(diào)血脂、降血糖和阻滯鈣通道。和厚樸酚可以抑制高脂飲食引起的動脈粥樣硬化形成和發(fā)展，還具有血管擴張和降壓作用，因此在心血管系統(tǒng)疾病治療方面有開發(fā)價值。

Honokiol is a hydrophobic compound of biphenol-type structure, and inhibit neointima formation and vascular stenosis induced by balloon angiogenesis. has the protective action against myocardial injury induced by diabetes, angiotensin II, sepsis, burned, coronary artery ligature-induced ischemia, and ischemia/reperfusion, and can block to occurrence and development of myocardial hypertrophy and fibrosis. Honokiol antagonizes lipopolysaccharides or ox-LDL-induced vascular endothelial cells injury, and inhibits proliferation and migration of vascular smooth muscle cells, and vascular remodeling and neovascularization. The basic mechanisms of cardiovascular protection of honokiol are antioxidation, anti-inflammation, hypoglycemia, hypolipidemia and blocking Ca²⁺ channel. It relieves hyperliposis diet-induced atherosclerosis, also has vascular dilation and antihypertensive effects. It has development value in the treatment of cardiovascular system diseases.