目的 探討連花清瘟顆粒聯(lián)合磷酸奧司他韋治療流行性感冒 （風(fēng)熱犯衛(wèi)證） 的療效及對患者免疫功能的影響。方法 前瞻性選取 2019年 1月—2020年 5月南通市中醫(yī)院收治的 140例流行性感冒 （風(fēng)熱犯衛(wèi)證） 患者，采用隨機(jī)對照非盲法將其分為對照組與試驗(yàn)組，每組各70例。兩組患者予以對癥治療，對照組在對癥基礎(chǔ)上采用磷酸奧司他韋膠囊治療，每次75 mg，每天2次，分別于早晚餐后30 min口服。試驗(yàn)組在對照組基礎(chǔ)上加用連花清瘟顆粒治療，每次1袋，每天3次，餐后30 min口服。兩組患者均連續(xù)治療5 d。評估兩組臨床療效及不良反應(yīng)。比較兩組治療前后中醫(yī)證候積分、γ-干擾素（IFN-γ）、白細(xì)胞介素-6（IL-6）以及T淋巴細(xì)胞亞型水平。結(jié)果 試驗(yàn)組總有效率較對照組顯著升高（P＜0.05）。兩組患者治療后中醫(yī)證候積分及IFN-γ、IL-6、CD8⁺水平均較同組治療前顯著降低（P＜0.05），試驗(yàn)組患者治療后中醫(yī)證候積分及 IFN-γ、IL-6、CD8⁺水平均較對照組顯著降低（P＜0.05）。兩組患者治療后 CD3⁺、CD4⁺及 CD4⁺/CD8⁺水平均較同組治療前顯著升高（P＜0.05），試驗(yàn)組患者治療后 CD3⁺、CD4⁺及 CD4⁺/CD8⁺水平均較對照組顯著升高（P＜0.05）。兩組均未發(fā)生不良反應(yīng)。結(jié)論 連花清瘟顆粒聯(lián)合磷酸奧司他韋膠囊治療流行性感冒（風(fēng)熱犯衛(wèi)證）的療效及安全性較高，其不僅能減輕患者中醫(yī)臨床癥狀，同時(shí)還能調(diào)節(jié)患者免疫功能，促進(jìn)患者早日康復(fù)。

Objective To explore the therapeutic effect of Lianhua Qingwen Granule combined with oseltamivir on influenza (wind heat offending wei syndrome) and its influence on immune function.Methods A total of 140 cases of influenza patients with influenza (wind heat offending wei syndrome) in Nantong Traditional Chinese Medicine Hospital from January 2019 to May 2020 were divided into experimental group and control group by prospective randomized controlled unblinded method, with 70 cases in each group. Patients in two groups were treated symptomatically. On this basis, patients in the control group were treated with Oseltamivir Phosphate Capsule, 75 mg each time, twice a day, taken orally 30 minutes after breakfast and dinner. Patients in the experimental group were treated with Lianhua Qingwen Granules on the basis of the control group, one bag per time, three times a day, and orally taken 30 minutes after meals. Both groups of patients were treated continuously for five days. The clinical efficacy and the adverse reactions of the two groups were evaluated. The scores of the TCM symptom, γ-interferon (IFN-γ), interleukin-6(IL- 6) and T-lymphocyte subtypes before and after treatment were compared between the two groups.Results The total effective rate of patients in the experimental group was significantly higher than that in the control group (P < 0.05). TCM symptom score and IFN-γ, IL-6 and CD8⁺of two groups of patients after treatment were lower than those before treatment (P < 0.05), and TCM symptom score and IFN- γ, IL-6 and CD8⁺ of patients in the experimental group after treatment were lower than those in the control group (P < 0.05). After treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in both groups were higher than those before treatment (P < 0.05),and those in the experimental group were higher than those in the control group (P < 0.05). There was no adverse reaction occurred in both groups.Conclusion Lianhua Qingwen Granule combined with oseltamivir has high efficacy and safety in the treatment of influenza (wind heat offending wei syndrome). It can not only alleviate the symptoms of patients in traditional Chinese medicine, but also regulate the immune function of patients and promote their early recovery.

R974

南通市市級科技計(jì)劃項(xiàng)目（MSZ20107）