中藥注射劑因藥物相互作用引起的不良反應(yīng)問(wèn)題日益凸顯，而細(xì)胞色素P450（CYP450）酶是影響藥物體內(nèi)處置過(guò)程的重要因素，其表達(dá)和功能的改變常常引起藥動(dòng)學(xué)的變化，是代謝性藥物相互作用的主要靶點(diǎn)。因此，開(kāi)展中藥注射劑與化學(xué)藥的藥物相互作用研究十分必要，就CYP450酶介導(dǎo)的中藥注射劑與化學(xué)藥相互作用的研究現(xiàn)狀以及常見(jiàn)的中藥注射劑對(duì)CYP450酶影響的研究進(jìn)行綜述，為中藥注射劑的臨床應(yīng)用和相互作用研究提供參考。

The adverse reactions caused by drug interactions in traditional Chinese medicine injections have become increasingly prominent. However, the herb-drug interaction caused by its combination with western medicine has attracted more and more attention. Cytochrome P450 (CYP450) enzyme is an important factor affecting the drug disposal process in vivo, and the change of its expression and function often leads to the change of pharmacokinetics, which is the main target of metabolic drug interaction. Therefore, it is necessary to study the herb-drug interaction of traditional Chinese medicine injections with chemical drugs. The current research status of traditional Chinese medicine injections mediated by CYP450 enzyme on chemotherapeutic drug interaction and the studies on the influence of common traditional Chinese medicine injections on CYP450 enzyme were reviewed, in order to provide reference for the clinical application and interaction research of traditional Chinese medicine injections.

R285.5；R965.3

天津市教委科研計(jì)劃項(xiàng)目（2021ZD030）