中藥藥效物質基礎研究是解釋中醫(yī)藥作用機制的基石，然而中藥復方作為一個復雜體系，作用機制與體內效應過程不明確等問題長期桎梏中醫(yī)藥事業(yè)的發(fā)展。藥動學-藥效學（PK-PD）相關性研究是動態(tài)表征和定量描述活性成分與藥理作用之間相關性的有效方法，將時間、濃度和效應結合起來，已經成為闡明中藥藥效物質基礎的技術策略，但是目前研究大都集中在結構明確的化學藥物，缺乏符合中醫(yī)藥發(fā)展模式的相關策略。因此，非常有必要深入挖掘新的研究策略，建立符合中醫(yī)藥特色的PK-PD模型，通過進行方法開發(fā)與技術重組，利用從化學物質基礎、關鍵成分的篩選、整合PK-PD相關性的多維整合的研究思路，引入代謝組學等現(xiàn)代技術手段，全方位、及時靈敏地表征藥效特點，評價藥動學考察藥物機制研究，旨在構建更易于發(fā)現(xiàn)藥效物質的技術體系，為闡明中藥復方的藥效物質基礎提供參考。

The research on the material basis of medicinal effect of traditional Chinese medicine (TCM) is the cornerstone of explaining the mechanism of action of TCM. However, as a complex system, the development of TCM has long been hindered by the unclear mechanism and effect process in vivo. Pharmacokinetic-pharmacodynamic (PK-PD) correlation study is an effective method to dynamically characterize and quantitatively describe the correlation between active ingredients and pharmacological actions. The combination of time, concentration and effect has become a technical strategy to clarify the material basis of the efficacy of TCM. However, most of the current research focuses on chemical drugs with clear chemical composition, and lacks relevant strategies in line with the development model of TCM. Therefore, it is very necessary to deeply explore new research strategies, establish a PK-PD model that conforms to the characteristics of TCM, conduct method development and technical reorganization, use multi-dimensional integration research ideas from the basis of chemical substances, the screening of key components, and the integration of PK-PD correlation, introduce modern technical means derived from metabonomics, and comprehensively and sensitively demonstrate the evaluation of pharmacodynamic characteristics, and pharmacodynamic study of drug mechanisms. The aim is to build a technical system that is easier to find effective substances, and to provide a reference for clarifying the material basis of the efficacy of TCM prescriptions.

國家自然科學基金資助項目（32174099，31473415，81001688）；山西省基礎應用項目面上項目（20210302123432）；名優(yōu)晉藥再開發(fā)山西省重點實驗室項目（202104010910001）；地產中藥功效物質研究與利用山西省重點實驗室項目（202105D121009）