腦水腫是缺血性腦卒中、腦出血、腦積水、肝衰竭等多種疾病的繼發(fā)性癥狀，臨床上治療腦水腫的中成藥主要有丹參類制劑（包括丹參注射液、復(fù)方丹參注射液和丹紅注射液）和三七類制劑（三七顆粒和血塞通注射液），它們具有活血化瘀、改善血液循環(huán)的作用；經(jīng)典名方桃核承氣湯具有逐瘀瀉熱的功效，通過活血化瘀、利水作用來改善腦水腫。其藥理作用主要是通過水通道、離子通道起作用，主要靶點為水通道蛋白、離子通道蛋白、血液中的基質(zhì)金屬蛋白酶。對相關(guān)中成藥及經(jīng)典名方治療腦水腫的藥理及臨床研究進(jìn)行歸納總結(jié)，以期為治療該病的新藥研發(fā)及臨床合理用藥提供依據(jù)。

Brain edema is a secondary symptom of ischemic cerebral infarction, cerebral hemorrhage, hydrocephalus, liver failure and other diseases. Clinically, Chinese patent medicines for the treatment of cerebral edema include Danshen preparations (such as Danshen Injection, Compound Danshen Injection and Danhong Injection) and Sanqi preparations (such as Sanqi Granules and Xuesaitong Injection), which have the effect of promoting blood circulation and removing blood stasis to improve blood circulation. The classic prescription for the treatment of cerebral edema is Taohe Chengqi Decoction, which has the effect of expelling stasis and purging heat. It can improve cerebral edema by promoting blood circulation and removing blood stasis and promoting diuresis. The treatment of cerebral edema mainly works through water channels and ion channels, and the main targets are aquaporins, ion channel proteins, and matrix metalloproteinases in the blood. In this study, the related Chinese patent medicines and traditional Chinese medicine decoctions in the treatment of cerebral edema were summarized by consulting the literature, in order to provide a basis for the development and rational use of new drugs for treating cerebral edema.

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