五味子是常用中藥材之一，在保肝、治療心腦血管疾病等方面發(fā)揮重要作用，其主要活性成分包括木脂素類、多糖類、揮發(fā)油及有機酸等成分。對五味子提取物及其有效成分治療心血管疾病的抗心肌炎癥、抗氧化損傷、抑制心肌細胞凋亡、緩解心肌纖維化等藥理作用及其機制進行綜述，發(fā)現(xiàn)五味子總木脂素可以調(diào)節(jié)核因子-κB信號通路、激活氮合酶途徑抑制炎癥因子及心肌細胞的凋亡，五味子乙素調(diào)節(jié)酪氨酸激酶2蛋白/信號轉(zhuǎn)導(dǎo)子與激活子3信號通路抑制氧化損傷，五味子提取物抑制Smad蛋白信號傳導(dǎo)發(fā)揮舒張心血管作用。

Schisandrae Chinensis Fructus is one of the commonly used Chinese medicine in clinic. It plays an important role in protecting liver and treating cardiovascular and cerebrovascular diseases. Its main active ingredients include lignans, polysaccharides, volatile oils and organic acids. The pharmacological effects and mechanisms of Schisandrae Chinensis Fructus extract and its active components in the treatment of cardiovascular diseases, such as anti-myocardial inflammation, anti-oxidative damage, inhibition of cardiomyocyte apoptosis and alleviating myocardial fibrosis, were reviewed. It was found that the total lignan of Schisandrae Chinensis Fructus can regulate the nuclear fact-κB signaling pathway, activate the nitrogen synthase pathway and inhibit inflammatory factors and cardiomyocyte apoptosis. Schisandrin regulates tyrosine kinase 2 / signal transductor and activator 3 signaling pathways to inhibit oxidative damage, and Schisandrae Chinensis Fructus extracts inhibit Smad protein signal transduction to exert diastolic cardiovascular effects.

R286.2