目的 評價天麻鉤藤顆粒治療原發(fā)性高血壓（EHT）的經(jīng)濟性，以期為衛(wèi)生醫(yī)療用藥資源的合理配置提供參考依據(jù)。方法 本研究采用TreeAge Pro軟件對天麻鉤藤顆粒＋硝苯地平控釋片（NCRT）vs單用NCRT干預EHT進行成本效果分析，干預周期為12周，并對結(jié)果進行敏感性分析和情境分析。結(jié)果 基礎分析結(jié)果顯示，兩組的增量成本效果比（ICER）值為65.15元，即相比于單用NCRT，使用天麻鉤藤顆粒聯(lián)合NCRT每多獲得1個單位的有效率，EHT患者需多花費65.15元；當患者的個人意愿支付價格高于65.15元時，天麻鉤藤顆粒＋NCRT組具有經(jīng)濟性的概率優(yōu)于單用NCRT組。敏感性分析結(jié)果驗證了基礎分析結(jié)果的穩(wěn)健性，天麻鉤藤顆粒組的臨床療效和NCRT組的用藥成本對研究結(jié)果有較大影響，當患者的個人意愿支付價格高于64元時，具有更高經(jīng)濟性概率的干預方案同基礎分析結(jié)果一致。結(jié)論 當個人意愿支付價格高于64元時，EHT患者選用天麻鉤藤顆粒聯(lián)合NCRT比單用NCRT在降低血壓方面更具有經(jīng)濟性。

Objective To evaluate the economic efficiency of Tianma Gouteng Granules (TGG) in treatment of essential hypertension (EHT), so as to provide reference for rational allocation of medical medication resources. Methods TreeAge Pro software was used to analyze the cost-effectiveness of TGG + nifedipine controlled released tablets (NCRT) versus NCRT alone for EHT intervention. The intervention period was 12 weeks, and sensitivity analysis and situational analysis were performed on the results. Results The basic analysis results showed that the ICER of the two groups was 65.15 yuan. In other words, compared with NCRT alone, TGG combined with NCRT cost 65.15 yuan more for each additional unit of effective rate. When the patient's personal willingness to pay was higher than 65.15 yuan, the economic probability of TGG plus NCRT was better than that of conventional therapy alone. The results of sensitivity analysis verified the robustness of the results of the basic analysis. The clinical efficacy of TGG combined with NCRT group and treatment cost of the NCRT group had a great impact on the results of the study. When the patients' personal willingness to pay more than 64 yuan, the TGG combined with NCRT group with higher economic probability was consistent with the results of the basic analysis. Conclusion When the individual willing to pay more than 64 yuan, TGG combined with NCRT is more economical than NCRT alone in reducing blood pressure in EHT patients.

R971

國家重點研發(fā)計劃項目（2018YFC1707400）