目的 探討濟(jì)生烏梅片對(duì)預(yù)防胃及十二指腸息肉內(nèi)鏡下切除術(shù)后復(fù)發(fā)的療效。方法 按照納入標(biāo)準(zhǔn)以2020年1月— 2022年3月在重慶市中醫(yī)院消化科門診或住院部就診，并在本院行胃鏡檢查及手術(shù)治療的胃和（或）十二指腸息肉患者共83例為研究對(duì)象，根據(jù)治療方案不同分為對(duì)照組（n＝42）和試驗(yàn)組（n＝41）。對(duì)照組采取胃鏡下息肉切除術(shù)［息肉切除方式包括息肉冷切除、息肉的氬氣刀治療術(shù)及黏膜切除術(shù)（EMR術(shù)）］治療，試驗(yàn)組在胃鏡下息肉切除后，繼續(xù)給予濟(jì)生烏梅片治療，每次3片，每日3次，連續(xù)服用3個(gè)月。比較兩組患者術(shù)后1年胃及十二指腸息肉的復(fù)發(fā)率、臨床癥狀緩解情況及腫瘤標(biāo)志物的變化情況。結(jié)果 兩組治療1年后患者臨床癥狀（腹脹、噯氣及腹痛）均有改善（P<0.05）。腫瘤標(biāo)志物CA72-4水平在兩組中治療后均有降低（P<0.05）。試驗(yàn)組術(shù)后息肉復(fù)發(fā)率（26.83%）明顯低于對(duì)照組（64.29%，P< 0.05）。結(jié)論 內(nèi)鏡下息肉切除術(shù)聯(lián)合術(shù)后濟(jì)生烏梅片治療可改善患者的主要臨床癥狀，降低CA72-4的表達(dá)。術(shù)后聯(lián)用濟(jì)生烏梅片對(duì)預(yù)防胃及十二指腸息肉術(shù)后復(fù)發(fā)療效佳。

Objective To explore the efficacy of Jisheng Wumei Tablets in preventing recurrence after endoscopic resection of gastric and duodenal polyps. Method According to the inclusion criteria, a total of 83 patients with gastric and/or duodenal polyps who visited the gastroenterology outpatient or inpatient department of Chongqing Traditional Chinese Medicine Hospital from January 2020 to March 2022 and underwent gastroscopy and surgical treatment in the hospital were studied. They were divided into a control group (n= 42) and an experimental group (n= 41) according to different treatment plans. The control group received polypectomy under gastroscopy [polypectomy methods include cold polypectomy, argon knife treatment of polyps, and mucosal resection (EMR)], while the experimental group continued to receive Jisheng Wumei Tablets after polypectomy under gastroscopy, taking three tablets each time, three times a day, for a continuous period of three months. Compare the recurrence rate, clinical symptom relief, and changes in tumor markers of gastric and duodenal polyps between two groups of patients one year after surgery. Results After one year of treatment, the clinical symptoms (bloating, belching, and abdominal pain) of both groups of patients improved (P<0.05). The level of tumor marker CA72-4 decreased in both groups after treatment (P< 0.05). The recurrence rate of postoperative polyps in the experimental group (26.83%) was significantly lower than that in the control group (64.29%, P< 0.05). Conclusion Endoscopic polypectomy combined with postoperative Jisheng Wumei Tablets can improve the main clinical symptoms of patients and reduce the expression of CA72-4. The combined use of Jisheng Wumei Tablets after surgery has a better therapeutic effect on preventing postoperative recurrence of gastric and duodenal polyps.

R975

重慶市衛(wèi)生計(jì)生委中醫(yī)藥科技項(xiàng)目（ZY201802076）