目的 系統(tǒng)評(píng)價(jià)卡介菌多糖核酸注射液（BCG-PSN）治療扁平疣的有效性及安全性。方法 檢索中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、維普中文科技期刊數(shù)據(jù)庫(kù)（VIP）、萬(wàn)方數(shù)據(jù)庫(kù)（Wanfang Data）、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)（CBM）和英文數(shù)據(jù)庫(kù)Science Direcct、PubMed、Web of Science，從建庫(kù)到2023年5月國(guó)內(nèi)外發(fā)表的BCG-PSN治療扁平疣的臨床隨機(jī)對(duì)照試驗(yàn)（RCT），利用Note Express文獻(xiàn)管理軟件篩選文獻(xiàn)，采用數(shù)據(jù)提取表提取資料并評(píng)價(jià)其質(zhì)量，最后采用Rev Man 5.1軟件及TSA v0.9軟件進(jìn)行Meta分析。結(jié)果 共納入14項(xiàng)RCTs，包括患者1 258例。Meta分析結(jié)果顯示：肌肉注射卡介菌多糖核酸治療扁平疣的痊愈率［RR＝1.62，95% CI（1.41，1.87），P<0.000 01］和有效率［RR＝1.17，95% CI（1.12，1.22），P<0.000 01］均高于對(duì)照組，復(fù)發(fā)率［RR＝0.34，95% CI （0.21，0.56），P<0.000 1］和不良反應(yīng)發(fā)生率［RR＝0.67，95% CI（0.54，0.84），P=0.000 6］均低于對(duì)照組。試驗(yàn)序貫分析結(jié)果顯示，BCG-PSN治療扁平疣的痊愈率證據(jù)安全可靠。結(jié)論 肌肉注射BCG-PSN治療扁平疣有良好的臨床療效，且安全性良好。

Objective To evaluate the efficacy and safety of BCG Polysaccharide Nucleic Acid Injection (BCG-PSN) in the treatment of verruca plana. Methods The databases of CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science and Science Direct were searched, limited the clinical randomized controlled trials (RCT) of BCG-PSN for the treatment of verruca plana published at home and abroad from the establishment of the database to May 2023. Note Express was used to screen the literature according to the inclusion and row criteria, and data extraction table was used to extract data and evaluate its quality. Finally, the Rev Man 5.1, and TSA v0.9 software was used to Meta-analyze. Results A total of 14 RCTs were included, including 1 258 patients. Meta-analysis results showed that intramuscular injection of BCG-PSN in the treatment of verruca plana showed a higher recovery rate [RR = 1.62, 95%CI (1.41, 1.87), P< 0.000 01] and effective rate [RR = 1.17, 95%CI(1.12, 1.22), P< 0.000 01] than the control group, the intramuscular injection of BCG polysaccharide nucleic acid can also reduce the recurrence rate [RR = 0.34, 95%CI (0.21, 0.56), P< 0.000 1] and the incidence of adverse reactions [RR = 0.67, 95%CI (0.54, 0.84), P= 0.000 6]. The sequential analysis of experiments results showed that the recovery rate of BCG-PSN was reliable. Conclusions The intramuscular injection of BCG BCG-PSN has good efficacy and safety in the treatment of verruca plana, which can provide evidence for future clinical use.

R986；R969.3

湖南創(chuàng)新型省份建設(shè)專(zhuān)項(xiàng)（2020SK2043）