分散片是一種新型口服固體制劑，相較于普通片劑，具有服用方便、崩解迅速、吸收起效快、生物利用度高及不良反應(yīng)小等優(yōu)點。近年來，隨著研究的不斷深入，國內(nèi)外出現(xiàn)了三維（3D）打印技術(shù)、掩味技術(shù)、增溶促溶技術(shù)、片劑分割技術(shù)等分散片制備新技術(shù)，另外還對其吸水率、潤濕時間、崩解時間、分散時間和分散均勻性、混懸度等體外質(zhì)量指標(biāo)進(jìn)行了深入研究探討。總結(jié)分散片在制備技術(shù)和質(zhì)量評價方面的研究進(jìn)展，旨在為分散片研究開發(fā)和質(zhì)量標(biāo)準(zhǔn)完善提供參考依據(jù)。

Dispersible tablets are a new type of oral solid dosage form with many advantages such as convenient administration, fast disintegration, rapid in vivo absorption and onset of action, high bioavailability and few adverse reactions when compared with common oral tablets. In recent years, along with much deeper research, some new preparing processes and techniques of dispersible tablets including 3D printing, taste-masking, solubilization and tablet-splitting techniques have appeared, and meantime, a few novel quality evaluation indicators of dispersible tablets such as water absorption ratio, disintegration time, in vitro dispersion time and uniformity of dispersion, suspension degree also intensively explored at home and abroad. The progress in the preparing technique and quality evaluation of dispersible tablets is reviewed in order to provide an important reference for studying and developing dispersible tablets and further improving their quality standards in future.

R943