目的 了解在真實(shí)世界中熱毒寧注射液治療手足口病的臨床用藥特點(diǎn)，為臨床應(yīng)用提供借鑒和參考。方法 采用頻數(shù)分析和關(guān)聯(lián)規(guī)則方法，對(duì)來自江蘇省3家三甲兒童?？漆t(yī)院信息系統(tǒng)（HIS）中使用熱毒寧注射液的手足口病患者一般信息、臨床用藥信息及合并用藥特征進(jìn)行統(tǒng)計(jì)分析。結(jié)果 使用熱毒寧注射液手足口病患者共3 486例，平均年齡為4.74歲，多為6歲以下兒童，占83.37%。主要分布在感染性疾病科，住院時(shí)間多集中于1～7 d，占86.40%。使用熱毒寧注射液的手足口病患者常合并有上呼吸道感染、腹瀉病、支氣管炎等，中醫(yī)證候多為濕熱郁蒸證，其次為風(fēng)熱犯肺證；熱毒寧注射液的給藥途徑主要為靜脈滴注，單次用藥劑量以4～7 mL最多，共1 725例患者，占49.58%；療程分布最多的為4～7 d，占總?cè)藬?shù)的58.45%。熱毒寧注射液的常見聯(lián)合用藥為開喉劍（支持度43.67%）、奧拉西坦（支持度35.40%）、苯扎氯胺（支持度26.82%）、利巴韋林（支持度24.53%），并常與抗病毒藥物、清熱解毒類中成藥等具有相似藥理作用的藥物合并使用。結(jié)論 熱毒寧注射液臨床用藥基本符合藥品說明書及手足口病診療指南，部分患者存在超說明書用藥情況，臨床醫(yī)生應(yīng)注意用藥規(guī)范，并評(píng)估合并用藥的種類及其相互作用，預(yù)防兒科藥品不良反應(yīng)的發(fā)生。

Objective To investigate the medication characteristics of Reduning Injection in treating hand-foot-mouth disease (HFMD) in the real world, so that we can provide guidance for its clinical use. Methods Cases of hospital information system (HIS) data were collected from three grade A children hospitals. The basic description method and assosiation rules were used to analyze the data about patient information, clinical characteristics and combined medication. Results Of all the 3 486 case of HFMD patients, the average age was 4.74 years, and 83.37% of patients were aged below 6 years. Most patients came from the department of infectious diseases, and the hospitalization day between one and seven was most, accounting for 86.40%. The complications were the upper respiratory tract infection, diarrhea and bronchitis, and the traditional Chinese medicine syndrome was damp-heat with exuberance of virulence and wind-heat invading lung. The route of administration was mostly intravenous infusion, with 1 725 patients (49.58%) receiving a dosage of 4—7 mL per dose for between four and seven days, accounting for 58.45% of the total number of people. The main combination drugs were Kaihoujian, oxiracetam, benzalkonium chloride and ribavirin, with confidence of 43.67%, 35.40%, 26.82% and 24.53% respectively. And Reduning Injection was often combined with drugs with similar phamacological effects such as antiviral drugs and antipyretic-detoxicate drugs. Conclusion Reduning Injection was basically complied with the drug instructions and guidelines of HFMD in practice. However, off-label use still existed, doctors should realize the hiding risks, observe the conconmitant medications and interactions so as to prevent adverse drug reactions in pediatrics.

R974

十三五南京市衛(wèi)生青年人才培養(yǎng)工程第三層次（QRX17173）；南京藥學(xué)會(huì)—常州四藥醫(yī)院藥學(xué)科研基金（2019YX026）