經(jīng)皮給藥系統(tǒng)（TDDS）可避免首關(guān)效應(yīng)、胃腸道破壞，為新型皮膚給藥系統(tǒng)，可通過控制釋放而延長治療效果，成為藥物制劑開發(fā)研究的熱點(diǎn)之一。但是，藥物的理化性質(zhì)以及皮膚屏障影響藥物的經(jīng)皮吸收。綜述了TDDS常用的促滲透技術(shù)，包括化學(xué)、物理、納米、天然促滲透技術(shù)；介紹了促滲透能力的測定方法，包括體外、離體和體內(nèi)評估皮膚滲透性的方法。通過對經(jīng)皮藥物遞送系統(tǒng)和經(jīng)皮吸收能力測定方法的歸納與總結(jié)，以期為TDDS的合理使用和快速發(fā)展提供參考。

The transdermal drug delivery system (TDDS) can avoid the first pass elimination and gastrointestinal disruption. It's a novel drug delivery system. It can prolong the therapeutic effect by controlling the release rate of drugs, which makes it one of the hot spots for drug formulation development and research. Nevertheless, the physical and chemical properties of drugs and the skin barrier influence the transdermal absorption of drugs. This paper describes the common penetration enhancing techniques used in TDDS, including chemical, physical, nano, and natural penetration enhancing techniques. In addition, methods for measuring skin permeability, including in vitro, ex vivo and in vivo are presented. The main purpose of this paper is to review recent advances in effective new strategies for transdermal drug delivery and methods for measuring transdermal absorption capacity. It is expected to provide a reference for the rational use of TDDS and rapid development.

R927.1；R945

國家自然科學(xué)基金資助項(xiàng)目（82173441）；四川省自然科學(xué)青年基金資助項(xiàng)目（2023NSFSC1548）