柴胡來源于傘形科植物柴胡Bupleurum chinense或狹葉柴胡B.scorzonerifolium的干燥根，其化學(xué)成分主要包括柴胡皂苷類、黃酮類、多糖類以及揮發(fā)油類等，主要有保肝、調(diào)血脂、抗炎等功效。在中醫(yī)臨床中，柴胡常作為君藥，應(yīng)用于治療各種肝臟疾病的中醫(yī)組方中。經(jīng)典名方半夏瀉心湯、澤瀉湯、溫膽湯、小柴胡湯、逍遙散等已用于治療代謝相關(guān)脂肪性肝病（NAFLD）。對柴胡有效成分及經(jīng)典名方改善NAFLD的臨床應(yīng)用、藥理作用及其機(jī)制進(jìn)行綜述，以期為深入研究提供理論支撐。

Radix Bupleuri is the dried root of the umbelliferae plant Bupleurum chinense DC. or B. scorzonerifolium Willd., and its chemical composition mainly includes Radix Bupleuri saponins, flavonoids, polysaccharides, and volatile oils, etc. It is mainly used to protect the liver, lower blood lipids, and anti-inflammatory effects. In traditional Chinese medicine, it is often used as a monarchical drug in Chinese medicine formulas for the treatment of various liver diseases. Classical prescriptions such as Banxia Xiexin Decoction, Zexie Decoction, Wendan Decoction, Xiao Chaihu Decoction, and Xiaoyao San have been used in the treatment of metabolic-dysfunction-associated fatty liver disease (MAFLD). Therefore, the clinical application, pharmacology, and the mechanism of action of the active ingredients of Radix Bupleuri and classical prescriptions for the improvement of MAFLD, which have been mentioned in recent years' related researches, are reviewed, in order to provide scientific and effective theoretical support.

R285.5

國家自然科學(xué)基金資助項(xiàng)目（82174099）；山西省基礎(chǔ)應(yīng)用項(xiàng)目面上項(xiàng)目（20210302123432）；名優(yōu)晉藥再開發(fā)山西省重點(diǎn)實(shí)驗(yàn)室資助項(xiàng)目（202104010910001）；地產(chǎn)中藥功效物質(zhì)研究與利用山西省重點(diǎn)實(shí)驗(yàn)室資助項(xiàng)目（201605D111004）