目的 系統(tǒng)評(píng)價(jià)抗感顆粒聯(lián)合奧司他韋治療兒童流行性感冒的有效性與安全性。方法 檢索中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、中國(guó)生物醫(yī)學(xué)文獻(xiàn)服務(wù)系統(tǒng)（SinoMed）、維普中文科技期刊數(shù)據(jù)庫(kù)（VIP）、萬(wàn)方數(shù)據(jù)庫(kù)（Wanfang Data）、PubMed、Cochrane Library、Springer Link、Embase數(shù)據(jù)庫(kù)中關(guān)于抗感顆粒聯(lián)合奧司他韋治療兒童流行性感冒的臨床隨機(jī)對(duì)照試驗(yàn)（RCT），檢索時(shí)間為建庫(kù)至2023年3月。采用Cochrane Handbook中的偏倚風(fēng)險(xiǎn)評(píng)估工具和RevMan 5.3軟件進(jìn)行文獻(xiàn)質(zhì)量評(píng)價(jià)與Meta分析。結(jié)果 共納入12項(xiàng)RCTs，共計(jì)1 201例患者，其中試驗(yàn)組601例、對(duì)照組600例。Meta分析結(jié)果顯示，相較于對(duì)照組，抗感顆粒聯(lián)合奧司他韋顆粒治療的總有效率更高[RR=1.23，95% CI（1.18，1.29）]，發(fā)熱[MD=-0.42，95% CI（-0.69，-0.15）]、咽痛[MD=-0.31，95% CI（-0.41，-0.21）]積分更低，退熱時(shí)間更短[MD=-1.38，95% CI（-1.67，-1.10）]，且兩組比較差異均有統(tǒng)計(jì)學(xué)意義（P＜0.000 01）；試驗(yàn)組與對(duì)照組的臨床癥狀咳嗽積分[MD=0.19，95% CI（-0.21，0.59），P=0.35]、不良反應(yīng)發(fā)生率[RR=2.36，95% CI（0.50，11.20），P=0.28]比較，無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論 抗感顆粒聯(lián)合奧司他韋治療兒童流行性感冒療效確切、安全性較好；但本研究尚有一定局限性，上述結(jié)論需更高質(zhì)量的隨機(jī)對(duì)照研究給予進(jìn)一步驗(yàn)證。

Objective To evaluate the efficacy and safety of Kanggan Granule combined with oseltamivir in the treatment of influenza. Methods CNKI, SinoMed, WanFang, VIP, PubMed, Cochrane Library, Springer Link, and Embase were searched by computer to collect the randomized controlled trial(RCT) of Kanggan Granule combined with oseltamivir in the treatment of influenza. The search aimed to identify clinical randomized controlled trials (RCTs) on the combined use of Kanggan granules and oseltamivir for treating influenza in children, the search deadline is from database establishment to March 2023. Meta-analysis performed by RevMan 5.4 software which is provided by Cochrane collaboration network. Result A total of 12 RCTs with 1 201 patients were included, 601 patients in trial group, and 600 patients in control group. The results of Meta-analysis showed that total effective rate of Kanggan Granule combined with oseltamivir in the treatment of influenza was significantly higher than that of oseltamivir alone [RR=1.23, 95%CI(1.18, 1.29), P＜0.000 01]. The fever score [MD=-0.42, 95%CI (-0.69, -0.15), P=0.003], the sore throat score [MD=-0.31, 95%CI (-0.41, -0.21), P＜0.000 01] were significantly lower than that of oseltamivir alone. The duration of fever were significantly shorter than that of oseltamivir alone [MD=-1.38, 95%CI (-1.67, -1.10), P＜0.000 01]. There was no significant difference in the cough score [MD=0.19, 95%CI (-0.21, 0.59), P=0.35] and the incidence of adverse reactions [RR=2.36, 95%CI (0.50, 11.20), P=0.28] between the two groups compared with the use of oseltamivir alone. Conclusion Kanggan Granule can effectively treat children with influenza, and will not increase the incidence of adverse events. However, there are few literatures, which needs further validation by a higher quality randomized controlled study.

R965.3；R969.4

中央高?；究蒲袠I(yè)務(wù)專(zhuān)項(xiàng)資助項(xiàng)目（2020-JYB-ZDGG-072）