重樓皂苷是重樓的主要活性成分，具有抗炎、抗氧化、抗腫瘤、抗菌、止血等多種藥理作用。重樓皂苷抗炎作用的主要機制包括調(diào)控炎癥因子、炎癥細胞及相關(guān)信號轉(zhuǎn)導通路等；其主要通過清除自由基、激活抗氧化酶活性、調(diào)節(jié)凋亡蛋白信號通路等發(fā)揮抗氧化作用；通過干擾相關(guān)信號通路、調(diào)控相關(guān)蛋白表達、抑制腫瘤細胞增殖、誘導周期阻滯、誘導腫瘤細胞程序性死亡、抑制腫瘤細胞轉(zhuǎn)移與侵襲、抑制腫瘤血管的生成及抑制腫瘤耐藥等機制發(fā)揮廣譜抗腫瘤作用。針對重樓皂苷抗炎、抗氧化、抗腫瘤的作用機制進行綜述，以期為深入研究和新藥研發(fā)提供依據(jù)。

As an important natural saponin, Rhizome Paridis saponins is the main active ingredient of the traditional Chinese medicine Rhizome Paridis, which has a variety of pharmacological effects such as anti-inflammatory, antioxidant, anti-tumor, antibacterial and anti-inflammatory, and hemostatic. The anti-inflammatory effect of Rhizome Paridis saponin is characterized by multiple doctrines and pathways, and its main mechanism of action includes the regulation of inflammatory factors, inflammatory cells, and associated signal transduction pathways; Rhizome Paridis saponin mainly exerts antioxidant effects through scavenging free radicals, activating antioxidant enzyme activities, and regulating apoptotic protein signaling pathways; Rhizome Paridis saponin has spectral antitumor effects, exerting antitumor effects by interfering with related signaling pathways, regulating related protein expression, inhibiting tumor cell proliferation, inducing cycle blockade, inducing programmed death of tumor cells, inhibiting tumor cell metastasis and invasion, inhibiting tumor cardiovascular generation, and inhibiting tumor drug resistance, among other mechanisms. The present review specifically summarized the potential mechanisms of antioxidant, anti-inflammatory, and antitumor of Rhizome Paridis, in order to provide a reference for further research and drug development of Rhizome Paridis, and reference for their application in clinical treatment.