目的 探討中成藥清咳平喘顆粒聯(lián)合阿莫西林治療成人急性支氣管炎的臨床療效。方法 選取2022年3月—2023年1月宿遷市中醫(yī)院收治的93例急性支氣管炎患者為研究對象,根據(jù)治療方法不同分為對照組(n=45)和試驗組(n=48)。對照組患者給予阿莫西林膠囊,每次0.5 g,每天3次。試驗組在對照組的基礎(chǔ)上加用清咳平喘顆粒,每次10 g,每天3次。兩組均連續(xù)治療7 d,觀察兩組患者治療前后臨床療效、中醫(yī)證候積分、臨床癥狀消失時間、簡易咳嗽程度評分表(CET)評分、血清炎癥因子[白細胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)、超敏C反應蛋白(hs-CRP)、降鈣素原(PCT)]水平,并進行組間差異比較。結(jié)果 試驗組總有效率(97.92%)顯著高于對照組(87.67%)(P＜0.05)。兩組均能降低中醫(yī)證候積分(咳嗽、咳痰、痰鳴音、喘息)、縮短臨床癥狀(咳嗽、咳痰、喘息)消失時間(P＜0.05),顯著降低咳嗽程度CET評分及血清IL-6、TNF-α、hs-CRP、PCT水平(P＜0.05),且試驗組效果均顯著優(yōu)于對照組(P＜0.05)。結(jié)論 清咳平喘顆粒聯(lián)合阿莫西林治療急性支氣管炎療效確切,能顯著提高臨床有效率,改善患者臨床癥狀,縮短患者病程,改善炎癥反應,具有臨床推廣應用價值。

Objective To explore the clinical efficacy of Chinese patent medicine Qingke Pingchuan Granules combined with amoxicillin in treatment of adult patients with acute bronchitis.Methods A total of 93 patients with acute bronchitis treated in Suqian Traditional Chinese Medicine Hospital from March 2022 to January 2023 were divided into control group(n=45) and experimental group(n=48). Patients in the control group were given Amoxicillin Capsule, 0.5 g once time, three times once day.On the basis of the control group, patients in the experimental group were added with Qingke Pingchuan Granules, 10 g once time,three times once day. All patients were treated for seven days. The clinical efficacy, TCM syndrome score, clinical symptom disappearance time, cough degree score, serum inflammatory factor level before and after treatment of the two groups were observed, and the differences between the two groups were compared.Results The total effective rate of the experimental group(97.92%) was significantly higher than that of the control group(87.67%)(P＜0.05). Traditional Chinese medicine syndrome scores(cough, expectoration, phlegm sounds, and wheezing) of patients in two groups were reduced, the disappearance time of clinical symptoms(cough, expectoration, and wheezing) were shortened(P＜0.05), cough severity CET scores and serum inflammatory factor levels [interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), high sensitivity C-reactive protein(hs-CRP), calcitonin(PCT)]were reduced significantly(P＜0.05), and effect of the experimental group was significantly stronger than the control group(P＜0.05). In addition, the TCM syndrome score of wheezing in the experimental group was significantly improved(P＜0.05).Conclusion Qingke Pingchuan Granules combined with amoxicillin is effective in treatment of acute bronchitis. It can significantly improve the clinical effective rate, improve the clinical symptoms, shorten the course of the disease, improve the inflammatory response, and has the value of clinical application.

R974