納米氧化鋅(ZnO-NPs)是直徑在1~100 nm的無機材料,具有靶向腫瘤細胞、對血液腫瘤細胞敏感的特性,而對正常細胞影響較小,在治療血液腫瘤方面逐漸成為研究熱點。ZnO-NPs通過阻滯細胞周期、抑制腫瘤細胞增殖、調(diào)控線粒體功能、通過釋放Zn²⁺來影響細胞穩(wěn)態(tài)等進而誘導腫瘤細胞凋亡,從而破壞腫瘤細胞穩(wěn)態(tài);還可增敏化療藥物,并作為生物傳感器,在治療血液腫瘤方面具有很大潛力。對ZnO-NPs的藥理作用及其在抗白血病、多發(fā)性骨髓瘤、淋巴瘤中的藥理機制進行綜述,以期為優(yōu)化血液腫瘤治療手段提供新策略。

Nano-zinc oxide(ZnO-NPs) is an inorganic material with a diameter of 1-100 nm, which has the characteristics of targeting tumor cells and being sensitive to blood tumor cells, but has little influence on normal cells, and has gradually become a research hotspot in the treatment of blood tumors. ZnO-NPs induces apoptosis by blocking cell cycle, inhibiting the proliferation of tumor cells, regulating mitochondrial function, and releasing Zn²⁺ to affect cell homeostasis, thus destroying the homeostasis of blood tumor cells. It can sensitize chemotherapy drugs and can be used as a biosensor, which has great potential in the treatment of blood tumors. The pharmacological effects of ZnO-NPs and its mechanism in leukemia, multiple myeloma and lymphoma were reviewed in order to provide new strategies for optimizing treatment methods.

R979.1

山東省自然科學基金資助項目(ZR2020KH023)