甘草是最常用的藥用植物，廣泛應(yīng)用于食品及制藥行業(yè)。甘草的化學(xué)成分主要有三萜皂苷類、黃酮類和多糖類等，具有抗氧化、免疫調(diào)節(jié)、抗病毒及抗炎保肝等多種藥理作用。現(xiàn)代研究發(fā)現(xiàn)甘草提取物及有效成分（甘草酸、甘草次酸、甘草查爾酮A、甘草總黃酮等）能通過調(diào)節(jié)糖脂代謝、減輕氧化應(yīng)激、改變腸道菌群、保護(hù)腸道屏障等機(jī)制達(dá)到改善及治療代謝相關(guān)脂肪性肝?。∕AFLD）的目的。綜述近年來甘草提取物及有效成分抗MAFLD的藥理作用及機(jī)制研究進(jìn)展，旨在為該類藥物的臨床合理應(yīng)用及新藥研發(fā)提供理論依據(jù)。

Licorice, as the most commonly used medicinal plant, is widely used in the food and pharmaceutical industries. Licorice contains primarily triterpene saponins, flavonoids, and polysaccharide, which have various pharmacological effects such as antioxidant, immune regulation, antiviral, anti-inflammatory and liver protection. Modern research has found that licorice extracts and active ingredients, such as glycyrrhizic acid, glycyrrhetinic acid, licochalcone A, licorice total flavonoids and licorice extracts, can achieve the purpose of improving and treating metabolic associated fatty liver disease (MAFLD) by regulating glucose and lipid metabolism, reducing oxidative stress, altering gut microbiota, protecting intestinal barrier. This review mainly summarizes the research progress on the pharmacological effects and mechanisms of licorice extracts and active ingredients in treating MAFLD in recent years, aiming to provide theoretical basis for the clinical rational application and new drug development of this type of medication.

R285.5；R965

天津市衛(wèi)生健康科技項(xiàng)目（TJWJ2022MS039）