柴胡加龍骨牡蠣湯是載于《傷寒論》的經(jīng)典名方，可和解樞機(jī)、通陽(yáng)泄熱、鎮(zhèn)驚安神，與圍絕經(jīng)期綜合征（PMS）樞機(jī)不利之病機(jī)關(guān)鍵相契合，臨床用于治療PMS療效突出。其作用機(jī)制主要涉及神經(jīng)內(nèi)分泌系統(tǒng)的調(diào)節(jié)；絲裂原活化蛋白激酶（MEK）/細(xì)胞外信號(hào)調(diào)節(jié)激酶（ERK）、雌激素受體β（ERβ）/腦源性神經(jīng)營(yíng)養(yǎng)因子（BDNF）/酪氨酸蛋白激酶受體B （TrkB）/5-羥色胺2A受體（5-HT_2A）、雌激素受體α（ERα）/磷脂酰肌醇3-激酶（PI3K）/絲氨酸蘇氨酸蛋白激酶（Akt）/γ-氨基丁酸（GABA）等相關(guān)信號(hào)通路的調(diào)控；ERα的O-連接β-N-乙酰葡糖胺（O-GlcNAc）修飾等。臨床研究在調(diào)理睡眠、情緒諸癥，改善神經(jīng)內(nèi)分泌及減輕炎癥方面已有一定進(jìn)展。對(duì)柴胡加龍骨牡蠣湯治療PMS的藥理及臨床研究進(jìn)行整理和分析總結(jié)，以期為臨床應(yīng)用及深入研究提供參考。

Chaihu Longgu Muli Decoction is a classic prescription contained in Discussion of Cold Damage. It can regulate the function of pivot, activate yang and dissipate heat, tranquilize and allay excitement, which is just in line with the key pathogenesis of dysfunction of pivot of perimenopausal syndrome (PMS). It is clinically used to treat PMS with outstanding efficacy, and its mechanism of action mainly involves the regulation of the neuroendocrine system; mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK), estrogen receptor β (ERβ)/brain-derived neurotrophic factor (BDNF)/tyrosine protein kinase receptor B (TrkB)/serotonin 2A receptor (5-HT_2A), estrogen receptor α (ERα)/phosphatidylinositol 3-kinase (PI3K)/serine threonine protein kinase (AKT)/γ-aminobutyric acid (GABA) and other related signaling pathways regulation; O-linked β-N-acetylglucosamine (O-GlcNAc) modification of ERα. Clinical research has made some progress in regulating sleep and mood, improving neuroendocrine and reducing inflammatory response. This article collates and analyzes the pharmacological and clinical studies of Chaihu Longgu Muli Decoction in the treatment of perimenopausal syndrome, in order to provide reference for the clinical application and basic research of Chaihu plusLonggu Muli Decoction.

R285.5，R287.4

黑龍江省中醫(yī)藥科研項(xiàng)目（ZYW2022-020）；省級(jí)名中醫(yī)專家傳承工作室建設(shè)項(xiàng)目（G20191503）