目的 探討小兒豉翹清熱顆粒聯(lián)合頭孢噻肟鈉治療兒童細(xì)菌性肺炎療效及對(duì)炎癥因子的影響。方法 選取2020年1月—2023年1月聊城市第二人民醫(yī)院收治的細(xì)菌性肺炎患兒108例，根據(jù)隨機(jī)數(shù)表法將其分為試驗(yàn)組與對(duì)照組，各54例。對(duì)照組給予注射用頭孢噻肟鈉治療，試驗(yàn)組在對(duì)照組基礎(chǔ)上聯(lián)合小兒豉翹清熱顆粒進(jìn)行治療。治療7 d后，評(píng)估兩組患兒臨床療效、中醫(yī)證候積分、不良反應(yīng)，對(duì)比兩組患兒治療前后免疫指標(biāo)及炎癥因子水平變化。結(jié)果 治療7 d后，試驗(yàn)組總有效率顯著高于對(duì)照組（P＜0.05）；兩組患兒治療前中醫(yī)證候積分、免疫指標(biāo)、炎癥因子水平比較差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）；治療后兩組各中醫(yī)證候積分、白細(xì)胞介素（IL）-6和C反應(yīng)蛋白（CRP）水平較本組治療前顯著降低（P＜0.05），免疫球蛋白（Ig）A、IgG、IgM水平較本組治療前顯著升高（P＜0.05），且試驗(yàn)組治療后各中醫(yī)證候積分、IL-6和CRP水平顯著低于對(duì)照組（P＜0.05），IgA、IgG、IgM水平顯著高于對(duì)照組（P＜0.05）；兩組患兒不良反應(yīng)發(fā)生率無顯著差異（P＞0.05）。結(jié)論 小兒豉翹清熱顆粒聯(lián)合頭孢噻肟鈉對(duì)兒童細(xì)菌性肺炎具有較好的療效，能夠顯著改善患兒中醫(yī)證候積分、免疫功能和炎癥反應(yīng)。

Objective To explore the curative effect of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium and its influences on inflammatory factors in children with bacterial pneumonia. Methods A total of 108 children with bacterial pneumonia admitted to Liaocheng Second People's Hospital were enrolled between January 2020 and January 2023. According to random grouping method, they were divided into experimental group and control group, 54 cases in each group. Patients in the control group were treated with cefotaxime sodium, while patients in experimental group were additionally treated with Xiao'er Chiqiao Qingre Granules. After seven days of treatment, clinical curative effect, scores of TCM syndromes and adverse reactions in the two groups were evaluated. The changes in levels of immune indexes and inflammatory factors before and after treatment were compared between the two groups. Results After 7 d of treatment, clinical curative effect of experimental group was significantly better than that of control group (P < 0.05). Before treatment, there was no significant difference in scores of TCM syndromes, immune indexes and inflammatory factors between the two groups (P > 0.05). After treatment, scores of TCM syndromes, levels of interleukin (IL)-6 and C-reactive protein (CRP) were significantly decreased (P < 0.05), while levels of immunoglobulin (Ig)A, IgG and IgM were significantly increased in both groups (P < 0.05). After treatment, scores of TCM syndromes, levels of IL-6 and CRP in experimental group were significantly lower than those in control group (P < 0.05), while levels of IgA, IgG and IgM were significantly higher than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Curative effect of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium is good in children with bacterial pneumonia, which can significantly improve TCM syndromes, immune function and inflammatory response.

R974