功能性消化不良（FD）作為功能性胃腸病，中醫(yī)臨床通過病癥結合的方式進行治療，將其分為脾虛氣滯證、肝胃不和證、脾胃濕熱證、脾胃虛寒證、寒熱錯雜證、肝郁脾虛證、肝郁氣滯證等證型。FD動物模型的構建依據(jù)證型特定的發(fā)病機制來模擬人體癥狀，檢測指標常采用行為學、胃腸動力學及相關蛋白水平等評估模型與FD患者的相似度。符合病癥的動物模型是開展藥效研究和藥效評價的前提和基礎，對FD中醫(yī)證型的造模方法及檢測指標進行整理和分析，旨在完善和優(yōu)化動物模型，為后續(xù)的藥物研究提供支持。

Functional dyspepsia (FD), as a functional gastrointestinal disease, is treated in traditional Chinese medicine through a combination of symptoms and symptoms. FD is divided into spleen deficiency and qi stagnation syndrome, liver stomach disharmony syndrome, spleen stomach damp heat syndrome, spleen stomach deficiency and cold syndrome, mixed cold and heat syndrome, liver depression and spleen deficiency syndrome, and liver depression and qi stagnation syndrome. The construction of FD animal models is based on the specific pathogenesis of syndrome types to simulate human FD symptoms, and detection indicators often use behavioral, gastrointestinal dynamics, and related protein levels to evaluate the similarity between the model and FD patients. Animal models that meet the symptoms are the prerequisite and foundation for conducting pharmacological research and evaluation. The modeling methods and detection indicators of traditional Chinese medicine syndrome types in FD are currently organized and analyzed, aiming to improve and optimize the FD animal model and provide support for subsequent drug research.

國家科技重大新藥創(chuàng)制資助項目（2015ZX09501004）；天津市科技計劃資助項目（16PTGCCX00090，17ZXXYSY00020）