功能性消化不良（FD）作為功能性胃腸病，中醫(yī)臨床通過(guò)病癥結(jié)合的方式進(jìn)行治療，將其分為脾虛氣滯證、肝胃不和證、脾胃濕熱證、脾胃虛寒證、寒熱錯(cuò)雜證、肝郁脾虛證、肝郁氣滯證等證型。FD動(dòng)物模型的構(gòu)建依據(jù)證型特定的發(fā)病機(jī)制來(lái)模擬人體癥狀，檢測(cè)指標(biāo)常采用行為學(xué)、胃腸動(dòng)力學(xué)及相關(guān)蛋白水平等評(píng)估模型與FD患者的相似度。符合病癥的動(dòng)物模型是開(kāi)展藥效研究和藥效評(píng)價(jià)的前提和基礎(chǔ)，對(duì)FD中醫(yī)證型的造模方法及檢測(cè)指標(biāo)進(jìn)行整理和分析，旨在完善和優(yōu)化動(dòng)物模型，為后續(xù)的藥物研究提供支持。

Functional dyspepsia (FD), as a functional gastrointestinal disease, is treated in traditional Chinese medicine through a combination of symptoms and symptoms. FD is divided into spleen deficiency and qi stagnation syndrome, liver stomach disharmony syndrome, spleen stomach damp heat syndrome, spleen stomach deficiency and cold syndrome, mixed cold and heat syndrome, liver depression and spleen deficiency syndrome, and liver depression and qi stagnation syndrome. The construction of FD animal models is based on the specific pathogenesis of syndrome types to simulate human FD symptoms, and detection indicators often use behavioral, gastrointestinal dynamics, and related protein levels to evaluate the similarity between the model and FD patients. Animal models that meet the symptoms are the prerequisite and foundation for conducting pharmacological research and evaluation. The modeling methods and detection indicators of traditional Chinese medicine syndrome types in FD are currently organized and analyzed, aiming to improve and optimize the FD animal model and provide support for subsequent drug research.

國(guó)家科技重大新藥創(chuàng)制資助項(xiàng)目（2015ZX09501004）；天津市科技計(jì)劃資助項(xiàng)目（16PTGCCX00090，17ZXXYSY00020）