苦白蹄來源于藥用擬層孔菌Fomitopsis officinalis的干燥子實體，具有抑菌消炎、止咳平喘、祛風(fēng)除濕、消腫止痛和抗癌的功效。對苦白蹄的化學(xué)成分（包括三萜酸類、甾體類、倍半萜類、多糖類）及其提取部位和有效成分對肝癌、乳腺癌、肺癌、胃癌等腫瘤細(xì)胞系的抑制作用進(jìn)行歸納和總結(jié)，以期為苦白蹄的深入研究和進(jìn)一步開發(fā)利用提供思路與依據(jù)。苦白蹄提取部位和有效成分抗腫瘤具有多成分、多靶點(diǎn)的特點(diǎn)，其作用機(jī)制包括抑制腫瘤細(xì)胞增殖、誘導(dǎo)其凋亡、抑制腫瘤細(xì)胞遷移和侵襲、增強(qiáng)機(jī)體免疫及抑制腫瘤血管生成。

Agarikon is the dried fruiting body of Fomitopsis officinalis, which has the functions of inhibiting bacteria and reducing inflammation, relieving cough and asthma, dispelling wind and removing dampness, relieving swelling and pain, and anticancer. The chemical components (including triterpenic acid, steroids, sesquiterpenoids and polysaccharides) and their inhibitory effects on liver cancer, breast cancer, lung cancer and gastric cancer were summarized. This paper provides some useful ideas and directions for the further research and development of Fomitopsis officinalis. The extraction sites and active components of Fomitopsis officinalis have the characteristics of multi-components and multi-targets for anti-tumor. The mechanism of action includes inhibition of tumor cell proliferation, induction of apoptosis, inhibition of tumor cell migration and invasion, enhancement of immunity and inhibition of tumor angiogenesis.

R285.5

黑龍江省應(yīng)用技術(shù)研究與開發(fā)計劃項目（GA19C009）