藥物治療是甲狀腺功能亢進(jìn)的主要治療方法,常用的抗甲狀腺藥物包括丙基硫氧嘧啶、甲巰咪唑及其前體藥物卡比馬唑。這些抗甲狀腺藥物可引起不同程度的肝損傷。雖然對(duì)抗甲狀腺藥物導(dǎo)致肝毒性的認(rèn)識(shí)已超過70年,但是近年來仍有一些新的報(bào)道和闡述。對(duì)常見抗甲狀腺藥物導(dǎo)致肝損傷的發(fā)生率、臨床病理特點(diǎn)、作用機(jī)制以及預(yù)防等方面的研究進(jìn)展進(jìn)行綜述和分析,為臨床安全、合理用藥提供參考。

Pharmacotherapy is the main treatment for hyperthyroidism. The commonly used antithyroid agent include propylthiouracil, methimazole and its precursor, carbimazol. These antithyroid agent can cause varying degrees of liver damage. Although antithyroid agent hepatotoxicity has been recognized for more than 70 years, there are still some new reports and explanations in recent years. This article reviews and analyzes the research progress in the incidence, clinicopathological features, mechanism and prevention of liver injury caused by common antithyroid agent, to provide reference for clinical safety and rational drug use.

R965.3

福建省教育廳中青年教師教育科研項(xiàng)目(JAT210174)