他汀類藥物調(diào)脂作用顯著,是一類較全面的調(diào)脂藥,能強(qiáng)效降低血清總膽固醇(TC)和低密度脂蛋白(LDL),在心血管疾病預(yù)防和治療中應(yīng)用廣泛。近年來,隨著他汀類藥物的廣泛應(yīng)用,對其不良反應(yīng)的研究也日趨深入。肝毒性是此類藥物產(chǎn)生的重要不良反應(yīng)之一,他汀類藥物在使用過程中偶有藥物性肝損傷(DILI)發(fā)生,對他汀類藥物致DILI影響因素、相關(guān)機(jī)制及防治策略的研究進(jìn)展進(jìn)行總結(jié),旨在為他汀類藥物臨床合理使用及DILI的預(yù)防提供依據(jù)。

Statins are a kind of comprehensive lipid-regulating drugs, which can effectively reduce serum total cholesterol (TC) and low density lipoprotein (LDL). Statins are widely used in the prevention and treatment of cardiovascular disease. In recent years, with the wide application of statins, the research on their adverse reactions is becoming increasingly in-depth. Hepatotoxicity is one of the important adverse reactions caused by such drugs. Drug-induced liver injury (DILI) occasionally occurs during the use of statins. This paper summarizes the research progress on the influencing factors, related mechanisms, and prevention and treatment strategies of DILI caused by statins, aiming to provide a basis for rational clinical use of statins and prevention of DILI.

R965.3