預知子(Akebiae Fructus)是武當特色中藥,具有抗炎、抗菌、抗腫瘤、抗抑郁等多種藥理作用。主要含有三萜皂苷類、綠原酸類等化學成分,在臨床使用中多以復方的形式治療肝癌、胃癌、乳腺癌、前列腺癌等多種腫瘤,尤其是對于消化系統(tǒng)腫瘤,具有很高的使用價值。結(jié)合國內(nèi)外文獻對預知子的化學成分、抗消化道腫瘤的藥理作用及相關機制、在臨床上常用的藥對配伍組合進行了歸納總結(jié),以期對明確預知子發(fā)揮藥理作用的有效成分提供一定參考。對抗消化道腫瘤藥理及作用機制的歸納總結(jié),有望對今后預知子抗消化道腫瘤作用機制的深入研究起到一定幫助作用。預知子在臨床上常以復方的形式發(fā)揮治療作用,而藥對為復方的基本構成單位,對預知子臨床上常用藥對的歸納總結(jié)可為復雜的復方研究提供基礎以及對預知子的臨床使用提供一定參考。

Akebiae Fructus, a Wudang local Chinese medicine, has various pharmacological effects such as anti-inflammatory, antibacterial, anti-cancer, and anti-depression effects. Its compounds include triterpenoid saponins, chlorogenic acid and others. It is clinically used to treat liver cancer, gastric cancer, breast cancer, prostate cancer and other cancers in the forms of formulas, espcially, digestive system cancers. In this study, we reviewed and summarized the chemicals, pharmacology in anti-digestive system cancers, and herbal pairs in clinical compatibility, it is expected to provide some reference for clarifying the active ingredients of Akebiae Fructus that exert pharmacological effects. The summary of anti-digestive system cancers pharmacology and mechanism of action is expected to play a certain role in the further study of anti-digestive system cancers mechanism of Akebiae Fructus in the future. Akebiae Fructus often plays a therapeutic role in the form of compound in clinic, and drug pairs are the basic constituent units of compound. The summary of commonly used drug pairs of Akebiae Fructus in clinic can provide a basis for complex compound research and a certain reference for the clinical use of Akebiae Fructus.

R285.5

國家自然科學基金面上項目(82274155);湖北省科技廳對外合作項目(2022EHB046);湖北省自然基金計劃(一般面上項目)(2023AFB925);武當特色中藥研究湖北省重點實驗室開放課題(WDCM2023001;WDCM2023016);“十四五”湖北省高等學校優(yōu)勢特色學科群(現(xiàn)代醫(yī)學)項目(2022XKQY3)