石斛屬 Dendrobium Sw. 中藥生物堿類成分結(jié)構(gòu)新穎，藥理作用豐富多樣，特別是在抗腫瘤方面的表現(xiàn)尤為突出，多種石斛屬中藥生物堿已被證實(shí)對肺癌、胃癌、肝癌、乳腺癌、結(jié)腸癌、宮頸癌等有顯著的抗腫瘤活性，顯示出新藥開發(fā)潛力。但目前對其抗腫瘤藥理作用及機(jī)制的系統(tǒng)分析仍然不足，使得在理解和應(yīng)用石斛屬生物堿的過程中存在一定的盲點(diǎn)和局限性。梳理并深入探討石斛屬中藥生物堿成分對不同癌癥的藥理作用，對其常規(guī)的抗腫瘤作用機(jī)制如誘導(dǎo)腫瘤細(xì)胞凋亡、增強(qiáng)機(jī)體免疫功能、抑制腫瘤細(xì)胞的遷移、細(xì)胞周期調(diào)控進(jìn)行解析，并揭示其可能的作用靶點(diǎn)，為其在抗腫瘤研究領(lǐng)域的深入探索和開發(fā)利用提供有力的參考和依據(jù)。

Alkaloids in traditional Chinese medicine of Dendrobium Sw. are novel in structure and have diverse pharmacological effects, especially in the field of anti-cancer. Many alkaloids from traditional Chinese medicine of Dendrobium Sw. have been shown to have significant anti-cancer activities against lung cancer, gastric cancer, liver cancer, breast cancer, colon cancer, and cervical cancer, indicating great potential for the development of new drugs. However, there is still insufficient systematic analysis of their anti-cancer pharmacological effects and mechanisms, which leads to blind spots and limitations in understanding and applying Alkaloids in traditional Chinese medicine of Dendrobium Sw. This review aims to clarify the pharmacological effects of alkaloids in traditional Chinese medicine of Dendrobium Sw. on different types of cancer, including inducing tumor cell apoptosis, enhancing immune function, inhibiting tumor cell migration, and regulating the cell cycle. It also explores possible target molecules, providing valuable references and evidence for further exploration and development of alkaloids in traditional Chinese medicine of Dendrobium Sw. in the field of anti-cancer research.

R285;R979.1

國家自然科學(xué)基金資助項(xiàng)目（82104316）；2022 年度南京市中醫(yī)藥科技專項(xiàng)（ZYYB202203）