目的 評估抑郁癥患兒體內(nèi)鹽酸舍曲林血漿谷濃度的分布特征和影響因素。方法 采用液相色譜-質(zhì)譜聯(lián)用技術(shù)測定2022年1月—2023年11月期間服用鹽酸舍曲林的119例抑郁癥患者兒的血漿谷濃度，分析鹽酸舍曲林血漿谷濃度的分布特征和影響因素。結(jié)果 119例患兒中14例患兒的鹽酸舍曲林血漿谷濃度＜10 ng·mL^-1，105例患兒鹽酸舍曲林谷濃度在有效血藥濃度范圍內(nèi)（10～150 ng·mL^-1）?；純旱柠}酸舍曲林給藥劑量與血漿谷濃度呈正相關(guān)，但相關(guān)性較差（r＝0.223，P＜0.05）。男性患兒的鹽酸舍曲林血漿谷濃度劑量比（CDR）值顯著高于女性患兒（t＝-2.399，P＜0.05）；漢族患兒的鹽酸舍曲林 CDR 值顯著高于維吾爾族患兒（t＝2.505，P＜0.05）；身體質(zhì)量指數(shù)（BMI）＞24.0 kg·m^-2患兒的鹽酸舍曲林 CDR 值顯著高于 BMI＜18.5 kg·m^-2和 18.5 kg·m^-2≤BMI≤24.0 kg·m^-2患兒（F＝15.345，P＜0.05）。結(jié)論 鹽酸舍曲林血漿谷濃度在抑郁癥患兒中的個體差異大，性別、民族和BMI可能影響鹽酸舍曲林血漿谷濃度。

Objective To evaluate the distribution characteristics and influencing factors of sertraline trough concentration in patients with depression in Xinjiang.Methods Liquid chromatography-mass spectrometry (LC-MS) was used to determine the plasma trough concentrations of 119 patients with depression who took sertraline from January 2022 to November 2023, and the distribution characteristics and influencing factors of sertraline trough concentrations were analyzed.Results Among the 119 children, the plasma trough concentration of sertraline < 10 ng·mL^-1, and the trough concentration of sertraline in 105 children was within the therapeutic concentration range (10—150 ng·mL^-1). The dose of sertraline administered was positively correlated with the plasma trough concentration, but the correlation was poor (r＝ 0.223, P < 0.05). The concentration to dose ratio (CDR) value of sertraline in male children was significantly higher than that of female children (t＝ - 2.399, P < 0.05), the CDR value of sertraline in Han children was significantly higher than that of Uygur children (t＝ 2.505, P < 0.05), and the CDR value of sertraline in children with body mass index (BMI) > 24.0 kg·m^-2 was significantly higher than that of children with BMI < 18.5 kg·m^-2 and 18.5 kg·m^-2 ≤ BMI ≤ 24.0 kg·m^-2 (F＝ 15.345, P < 0.05).Conclusion The trough plasma concentration of sertraline varies widely among children with depression, and gender, ethnicity, and BMI may affect the trough plasma concentration of sertraline.

R917

新疆維吾爾自治區(qū)人民醫(yī)院科研基金資助項目（20220214）