氣相色譜-離子遷移譜（GC-IMS）是一種可快速分離揮發(fā)性氣體并靈敏檢測揮發(fā)性有機(jī)成分（VOCs）的新興技術(shù)，具有操作簡單、適用范圍廣泛等優(yōu)點(diǎn)。鑒于氣味是中藥的突出特點(diǎn)且在中藥質(zhì)量評價(jià)中占有重要地位，近年來該技術(shù)在中藥領(lǐng)域的應(yīng)用頻率增長迅速。在介紹GC-IMS技術(shù)的原理、相關(guān)參數(shù)的基礎(chǔ)上，對GC-IMS在中藥質(zhì)量評價(jià)領(lǐng)域的應(yīng)用進(jìn)行了梳理和歸納，包括中藥揮發(fā)性成分的表征、對中藥真?zhèn)?、基原、產(chǎn)地的鑒別以及根據(jù)氣味變化對中藥采收、貯存時(shí)期、加工炮制品的判斷等方面，并對該技術(shù)目前存在的問題和策略進(jìn)行了討論，以期為GC-IMS技術(shù)在中藥領(lǐng)域深入應(yīng)用提供參考。

Gas chromatography-ion migration spectrometry (GC-IMS) is a new technology for rapid separation of volatile gases and sensitive detection of volatile organic components (VOCs). It has the advantages of simple operation and wide application. Since odor is a prominent feature of Chinese materia medica (CMM) and plays an important role in the quality evaluation of CMM, the application frequency of this technology in the field of CMM has increased rapidly in recent years. Based on the introduction of the principle and related parameters of GC-IMS technology, the application of GC-IMS in the field of CMM quality evaluation was sorted out and summarized, including the characterization of volatile components of CMM, the identification of authenticity, origin and origin of CMM, and the judgment of harvesting, storage period and processed products of CMM according to odor changes. The existing problems and strategies of GC-IMS technology are discussed in order to provide reference for the further application of GCIMS technology in the field of CCM.

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國家自然科學(xué)基金資助項(xiàng)目（81774452，81001646）;河南省衛(wèi)生健康中青年學(xué)科帶頭人專項(xiàng)（HNSWJW-2020014）;河南省中醫(yī)科學(xué)研究基地專項(xiàng)（2021JDZY036）;國家中醫(yī)藥管理局青年岐黃學(xué)者培養(yǎng)項(xiàng)目（國中醫(yī)藥人教函［2022］256號）;河南省中醫(yī)藥科學(xué)研究專項(xiàng)（2023ZY2034）;河南省自然科學(xué)基金項(xiàng)目杰出青年科學(xué)基金項(xiàng)目（242300421023）