金釵石斛為我國(guó)傳統(tǒng)中藥，具有益胃生津、滋陰清熱等功效，其質(zhì)量標(biāo)準(zhǔn)的建立一直是熱點(diǎn)研究問題。金釵石斛主要包含生物堿類、菲類、聯(lián)芐類、倍半萜類、多糖等多種化合物，主要具有改善糖脂代謝、保護(hù)神經(jīng)系統(tǒng)、調(diào)節(jié)免疫反應(yīng)、抗腫瘤等多種作用。在金釵石斛化學(xué)成分及藥理研究基礎(chǔ)上，基于中藥質(zhì)量標(biāo)志物（Q-Marker）的概念，分析金釵石斛植物親緣關(guān)系、生長(zhǎng)年限、化學(xué)成分可測(cè)性、不同炮制方法、傳統(tǒng)功效及網(wǎng)絡(luò)藥理學(xué)預(yù)測(cè)等，對(duì)金釵石斛的Q-Marker進(jìn)行預(yù)測(cè)分析。選取化學(xué)成分可測(cè)定、功效相關(guān)的、成分含量較高的藥效活性成分，石斛堿、毛蘭素、石斛酚、moscatin可作為金釵石斛的Q-Marker。探討可表征金釵石斛質(zhì)量成分指標(biāo)與藥理作用及臨床應(yīng)用的內(nèi)在關(guān)聯(lián)性，為完善其質(zhì)量標(biāo)準(zhǔn)提供依據(jù)。

Dendrobium nobile is a traditional Chinese herbal medicine, which has the effects of nourishing the stomach, nourishing yin and clearing heat, and the establishment of its quality standards has always been a hot research issue. In this paper, the research status of the pharmacodynamic relationship of D. nobile is reviewed from the aspects of chemical composition and pharmacological effects, which mainly contain alkaloids, phenanthrene, bibenzyls, sesquiterpenoids, polysaccharides and other compounds, which mainly have various effects such as improving glucose and lipid metabolism, protecting the nervous system, regulating immune response, and anti-tumor. On the basis of the research on the chemical composition and pharmacology of D. nobile and based on the concept of quality marker (Q-Marker) in traditional Chinese medicine, the plant kinship, growth years, chemical composition measurability, different processing methods, traditional efficacy and network pharmacological prediction of D. nobile were analyzed, and the Q-Marker of D. nobile was predicted and analyzed. The pharmacodynamic active ingredients with measurable chemical composition, related efficacy and high component content were selected, and it was preliminarily suggested that dendrobine, mullanin, dendrobol and moscatin should be used as quality markers of D. nobile. To explore the internal correlation between the quality component indexes and pharmacological effects and clinical application of D. nobile hairpin, so as to provide a basis for improving its quality standards.

R285

貴州省高等學(xué)校中藥（民族藥）藥性與效應(yīng)研究重點(diǎn)實(shí)驗(yàn)室資助項(xiàng)目（黔教技［2023］018號(hào)）;貴州中醫(yī)藥大學(xué)國(guó)家與省級(jí)科技創(chuàng)新人才團(tuán)隊(duì)培育項(xiàng)目（貴中醫(yī)TD合字〔2023〕003號(hào)）;貴州省李輝武中藥炮制技術(shù)傳承基地建設(shè)項(xiàng)目（黔中醫(yī)藥函〔2024〕22號(hào)）;全國(guó)老藥工王建科傳承工作室（黔中醫(yī)藥函〔2024〕42號(hào)）