合歡Albizia julibrissin是一種藥食兩用的中藥材，在臨床中應(yīng)用廣泛。合歡的主要藥用部位有合歡皮和合歡花，內(nèi)含多種有效成分，具有抗炎、抗氧化、抗抑郁、鎮(zhèn)靜催眠等多種藥理作用。研究顯示合歡皮和合歡花及有效成分能通過調(diào)節(jié)神經(jīng)遞質(zhì)表達、減輕氧化應(yīng)激及炎癥反應(yīng)、調(diào)控相關(guān)信號通路等機制起到改善及治療抑郁癥、焦慮癥等精神疾病的目的。主要對合歡皮、合歡花及有效成分抗抑郁和抗焦慮等治療精神疾病的藥理作用及機制的研究現(xiàn)狀進行綜述，旨在為合歡作為抗精神疾病藥物的開發(fā)與應(yīng)用提供參考。

Albizia julibrissin is a medicinal and edible Chinese herbal medicine, which is widely used in clinical practice. The main medicinal parts of A. julibrissin are bark and flowers, which contain a variety of active ingredients and have many pharmacological effects such as anti-inflammatory, antioxidant, antidepressant, sedative and hypnotic. Studies have shown that the extracts and active ingredients of A. julibrissin can improve and treat mental disorders such as depression and anxiety by regulating the expression of neurotransmitters, reducing oxidative stress and inflammatory response, and regulating related signaling pathways. The research status of the pharmacological effects and mechanisms of the extracts of A. julibrissin and its active ingredients against mental diseases were reviewed, in order to provide reference for the development and application of A. julibrissin as an anti-mental diseases drug.

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廣西自然科學(xué)基金重點項目（2023GXNSFDA026048）;廣西研究生教育創(chuàng)新計劃項目（YCSW2024427）