目的 研究滑膜炎顆粒中丹參素、新綠原酸、原兒茶醛、綠原酸、隱綠原酸、咖啡酸、迷迭香酸和丹酚酸 B在小腸不同部位（十二指腸、空腸、回腸）的吸收差異，探究滑膜炎顆粒主要成分的腸吸收特性。方法 建立在體單向腸灌流模型，采用高效液相色譜（HPLC）法檢測(cè)以上8個(gè)指標(biāo)性成分的濃度；考察不同腸段對(duì)8個(gè)指標(biāo)性成分的吸收情況，計(jì)算腸吸收參數(shù)。結(jié)果 8個(gè)指標(biāo)性成分的表觀滲透系數(shù)（P_app）均大于1.2×10^-3 cm·min^-1，說(shuō)明各成分在不同腸段中的吸收情況均良好；各成分在空腸的吸收情況最好，其次是回腸和十二指腸。結(jié)論 滑膜炎顆粒各指標(biāo)性成分在小腸中的吸收情況良好，符合口服制劑的要求，為探討滑膜炎制劑的主要藥效成分及其作用特點(diǎn)的研究提供參考。

Objective To study the absorption differences of danshensu, neochlorogenic acid, protocatechualdehyde, chlorogenic acid, cryptochlorogenic acid, caffeic acid, rosmarinic acid, and salvianolic acid B in Huamoyan Granules in different parts of the small intestine (duodenum, jejunum and ileum), and to investigate the intestinal absorption characteristics of the main components of Huamoyan granules. Methods An in situ single-pass intestinal perfusion method was established, and the concentrations of the above eight index components were detected by high performance liquid chromatography (HPLC); the absorption of the eight index components in different intestinal segments was investigated, and the intestinal absorption parameters were calculated. Results The apparent permeability coefficients (P_app) of the eight index ingredients were all greater than 1.2 × 10^-3 cm·min^-1, indicating that the absorption of each ingredient was good in different intestinal segments; the absorption of each ingredient was best in the jejunum, followed by the ileum and duodenum. Conclusion The absorption of each index ingredient in Huamoyan preparation in the small intestine was good, which was in line with the requirements of oral preparation, and also provided an objective basis for exploring the study of the main pharmacodynamic components of Huamoyan preparation and their action characteristics.

R917

國(guó)家中醫(yī)藥管理局高水平建設(shè)學(xué)科（zyyzdxk-2023272）