目的 總結 2000 年以來巴戟天的研究進展，預測其未來研究熱點和趨勢。方法 使用 CiteSpace文獻計量學方法，分別從中國學術期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)據(jù)知識服務平臺、中國生物醫(yī)學文獻數(shù)據(jù)庫（SinoMed）、維普生物醫(yī)學數(shù)據(jù)庫（VIP）、PubMed和Web of Science數(shù)據(jù)庫中，收集巴戟天相關的中英文文獻，整理去重后采用CiteSpace等軟件分別對中英文文獻的發(fā)文量、作者、發(fā)文機構、文獻被引頻次、關鍵詞等進行統(tǒng)計和分析。結果 共納入文獻2 076篇，其中中文文獻1 636篇，英文文獻440篇。可視化分析結果顯示巴戟天相關的年發(fā)文量總體呈現(xiàn)增長的態(tài)勢。中、英文收錄文獻最多的期刊分別是《中藥材》和Molecules。被引頻次前10的中英文文獻主要研究方向為巴戟天抗抑郁、抗骨質疏松、抗炎等藥理作用。作者合作網(wǎng)絡分析顯示作者之間的合作不夠密切，且該領域主要由國內學者進行研究。對中文文獻的關鍵詞分析發(fā)現(xiàn)：頻數(shù)最高的關鍵詞為“藥理作用”；中心性最大的關鍵詞是“成分分析”；產生了 10個聚類，主要集中在藥理作用、成分分析、臨床應用等方面；突現(xiàn)詞有15個，其中“抗抑郁”的突現(xiàn)性最高。對英文文獻的關鍵詞分析發(fā)現(xiàn)：“抗抑郁”是頻數(shù)最大、中心性最高的關鍵詞；生成了 8 個聚類，主要集中在抗抑郁、抗炎作用及其機制研究上；突現(xiàn)詞有 17個，其中“抗炎”突現(xiàn)性最高。結論 當前巴戟天的研究涉及化學成分、藥理作用、藥物配伍和質量控制等方面，抗抑郁和抗骨質疏松等藥理作用可能成為未來的研究重點。部分藥理作用研究仍處于實驗階段，相應的臨床制劑開發(fā)需要進一步推進。

Objective To summarize the research progress on Morinda officinalis since 2000 and to predict future research hotspots and trends. Methods Using the bibliometric method of CiteSpace, the research progress on M. officinalis was analyzed to identify research hotspots and trends. Relevant Chinese and English literature on M. officinalis was extracted from the China National Knowledge Infrastructure (CNKI), VIP, Wanfang, SinoMed, PubMed, and Web of Science databases. After deduplication, CiteSpace and other software were used to statistically analyze the publication volume, authors, institutions, citation frequency, and keywords of the literature in both languages. A total of 2 076 articles were included, comprising 1 636 Chinese articles and 440 English articles. Results A total of 2 076 articles were included in the analysis, among which 1 636 were in Chinese and 440 in English. The visualization analysis results indicate that the annual publication volume related to M. officinalis has shown an overall increasing trend. The journals with the most articles on M. officinalis in Chinese and English were "Chinese Herbal Medicines" and "Molecules, " respectively. The top 10 most cited Chinese and English articles primarily focused on the pharmacological effects of M. officinalis, such as its antidepressant, anti-osteoporotic, and anti-inflammatory properties. The author collaboration network analysis revealed that collaboration among authors was not very close, and the field was mainly studied by domestic scholars. Keyword analysis of Chinese literature showed that the most frequent keyword was "pharmacological effects", and the keyword with the highest centrality was "component analysis." Ten clusters were identified, mainly focusing on pharmacological effects, component analysis, and clinical applications. There were 15 burst terms, with "antidepressant" having the highest burst strength. In the analysis of English literature, "antidepressant" was the keyword with the highest frequency and centrality. Eight clusters were identified, mainly focusing on antidepressant, anti-inflammatory effects, and their mechanisms. There were 17 burst terms, with "anti-inflammatory" having the highest burst strength. Conclusion Current research on M. officinalis involves chemical components, pharmacological effects, drug compatibility, and quality control. Pharmacological effects such as antidepressant and anti-osteoporotic activities may become key focuses of future research. Some pharmacological studies are still in the experimental stage, and the development of corresponding clinical formulations needs further advancement.

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云浮市2022年中醫(yī)藥（南藥）產業(yè)創(chuàng)新團隊項目（云科函［2022］71號）